AC 187

Tocris Bioscience, part of Bio-Techne | Catalog # 3419

COA / SDS

Potent and selective amylin antagonist

Key Product Details

Description:	Potent and selective amylin antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	2890.25

View Full Technical Details for AC 187

Technical Data
Citations

Biological Activity for AC 187

AC 187 is an orally active, potent amylin receptor antagonist (IC₅₀ = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.

Technical Data for AC 187

M. Wt	2890.25
Formula	C₁₂₇H₂₀₅N₃₇O₄₀
Single Letter Sequence	VLGKLSQELHKLQTYPRTNTGSNTY (Modifications: Val-1 = N-terminal Ac, Tyr-25 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	151804-77-2
PubChem ID	16133792
InChi Key	ZLFXHYNEZYAYPG-AABHONRUSA-N
Smiles	CC(C)C[C@H](NC(=O)[C@@H](NC(C)=O)C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AC 187

Solubility

Soluble to 1mg/ml in water

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References for AC 187

References are publications that support the biological activity of the product.

Gedulin Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187. Regul.Pept. 2006 PMID: 16914214
Reidelberger Amylin receptor blockade stimulates food intake in rats. Am.J.Physiol.Inter.Comp.Physiol. 2004 PMID: 15130879
Jhamandas and MacTavish Antagonist of the amylin receptor blocks β-amyloid toxicity in rat cholinergic basal forebrain neurons. J.Neurosci. 2004 PMID: 15201330