ABT 702 hydrochloride

Name: ABT 702 hydrochloride
Brand: Tocris Bioscience
SKU: 2372

Tocris Bioscience, part of Bio-Techne | Catalog # 2372

Citations (13)

COA / SDS

Adenosine kinase inhibitor; orally active

Key Product Details

Description:	Adenosine kinase inhibitor; orally active
Chemical Name:	5-(3-Bromophenyl)-7-[6-(4-morpholinyl)-3-pyrido[2,3-d]byrimidin-4-amine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	499.79

View Full Technical Details for ABT 702 hydrochloride

Technical Data
Citations

Biological Activity for ABT 702 hydrochloride

ABT 702 hydrochloride is a potent non-nucleoside adenosine kinase inhibitor (IC₅₀ = 1.7 nM), selective over other sites of adenosine interaction (A₁, A_2A and A₃ receptors, adenosine transporter and adenosine deaminase). Displays oral activity in animal models of pain and inflammation.

Technical Data for ABT 702 hydrochloride

M. Wt	499.79
Formula	C₂₂H₁₉N₆OBr.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2624336-92-9
PubChem ID	16760265
InChi Key	KXHYOZCVILMBFV-UHFFFAOYSA-N
Smiles	NC1=C2C(N=C(C3=CN=C(N4CCOCC4)C=C3)C=C2C5=CC(Br)=CC=C5)=NC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ABT 702 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	53.66	100

Preparing Stock Solutions for ABT 702 hydrochloride

The following data is based on the product molecular weight 499.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	10.00 mL	20.01 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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References for ABT 702 hydrochloride

References are publications that support the biological activity of the product.

Kowaluk ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties II. In vivo characterization in the rat. J.Pharmacol.Exp.Ther. 2000 PMID: 11082454
Lee Discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor. J.Med.Chem. 2001 PMID: 11405650
Jarvis ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2, 3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties: I In vitro characterization and acute antinociceptive J.Pharmacol.Exp.Ther. 2000 PMID: 11082453