ABP 688
Tocris Bioscience, part of Bio-Techne | Catalog # 5229
High affinity human mGlu5 antagonist
Discontinued Product
5229 has been discontinued.
View all Group I mGluR Antagonists products.
Key Product Details
Description
High affinity human mGlu5 antagonist
Product Description
ABP 688 is a high affinity human mGlu5 receptor antagonist (Ki = 1.7 nM). Inhibits glutamate-induced calcium release from L(tk-) cells expressing human mGlu5 receptors (IC50 = 2.3 nM).Product Specifications
Molecular Weight
240.30
Formula
C15H16N2O
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3-[2-(6-Methyl-2-pyridinyl)ethynyl]-2-cyclohexene-1-one O-methyloxime
CAS Number
924298-51-1
PubChem ID
11481862
InChI Key
CNNZLFXCUQLKOB-BMRADRMJSA-N
SMILES
CC1=CC=CC(C#CC(CCC2)=C/C2=N/OC)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 12.02 | 50 | |
| DMSO | 24.03 | 100 |
Preparing Stock Solutions
for ABP 688
The following data is based on the product molecular weight 240.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.16 mL | 20.81 mL | 41.61 mL |
| 5 mM | 0.83 mL | 4.16 mL | 8.32 mL |
| 10 mM | 0.42 mL | 2.08 mL | 4.16 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.83 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hintermann ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg.Med.Chem. 2007 PMID: 17110115
Product Specific Notices for ABP 688
For research use only
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