α-MSH

Name: α-MSH
Brand: Tocris Bioscience
SKU: 2584

Tocris Bioscience, part of Bio-Techne | Catalog # 2584

Citations (13)

COA / SDS

Endogenous melanocortin receptor agonist

Key Product Details

Description:	Endogenous melanocortin receptor agonist
Alternative Names:	α-Melanotropin,α-Melanocyte-stimulating hormone
Purity:	≥95% (HPLC)
Molecular Weight:	1664.9

View Full Technical Details for α-MSH

Technical Data
Citations

Biological Activity for α-MSH

α-MSH is an endogenous melanocortin receptor agonist (K_i values are 0.12, 31, 660 and 5700 nM for MC₁, MC₃, MC₄ and MC₅ receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

Technical Data for α-MSH

M. Wt	1664.9
Formula	C₇₇H₁₀₉N₂₁O₁₉S
Single Letter Sequence	SYSMEHFRWGKPV (Modifications: Ser-1 = N-terminal Ac, Val-13 = C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	581-05-5
PubChem ID	16132144
InChi Key	WHNFPRLDDSXQCL-UAZQEYIDSA-N
Smiles	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(C)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for α-MSH

Solubility

Soluble to 0.6mg/ml in water

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References for α-MSH

References are publications that support the biological activity of the product.

Mizusawa Alpha-melanocyte stimulating hormone and oxyt. induced penile erections, and intracavernous pressure increases in the rat. J.Urol. 2002 PMID: 11792967
Yamaoka-Tojo Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure. Intern.Med. 2006 PMID: 16679696
Wikber Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 1999 PMID: 10443584