A 1120
Tocris Bioscience, part of Bio-Techne | Catalog # 3793
High affinity retinol-binding protein 4 (RBP4) ligand
Key Product Details
Description
High affinity retinol-binding protein 4 (RBP4) ligand
Product Description
A 1120 is a high affinity retinol-binding protein 4 (RBP4) ligand (Ki = 8.3 nM); non-retinoid. Selective against a range of different cellular targets. As efficacious as fenretinide (Cat. No. 1396) in the reduction of serum RBP4 and retinol. Displaces transthyretin (TTR) from RBP4-TTR complexes.Product Specifications
Molecular Weight
392.37
Formula
C20H19F3N2O3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
CAS Number
1152782-19-8
PubChem ID
25138295
InChI Key
MEAQCLPMSVEOQF-UHFFFAOYSA-N
SMILES
O=C(NC3=C(C(O)=O)C=CC=C3)N1CCC(C2=C(C(F)(F)F)C=CC=C2)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.24 | 100 | |
| Ethanol | 9.81 | 25 |
Preparing Stock Solutions
for A 1120
The following data is based on the product molecular weight 392.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.74 mL | 25.49 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.10 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Motani Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J.Biol.Chem. 2009 PMID: 19147488
- Manolescu All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases Ins sensitivity in diabetic mice. J.Nutr. 2009 PMID: 20032483
Product Specific Notices for A 1120
For research use only
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