Fenretinide is a synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.

Product Specifications

Molecular Weight

391.55

Formula

C₂₆H₃₃NO₂

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(4-Hydroxyphenyl)retinamide

CAS Number

65646-68-6

PubChem ID

5288209

InChI Key

AKJHMTWEGVYYSE-FXILSDISSA-N

SMILES

CC(/C=C/C1=C(C)CCCC1(C)C)=C\C=C\C(C)=C\C(=O)NC1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.16	100
	Ethanol	39.16	100

Preparing Stock Solutions for Fenretinide

The following data is based on the product molecular weight 391.55

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.77 mL	25.54 mL
5 mM	0.51 mL	2.55 mL	5.11 mL
10 mM	0.26 mL	1.28 mL	2.55 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

Calculators

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Takahashi Antioxidant properties of N-(4-hydroxyphenyl)retinamide (fenretinide). Biol.Pharm.Bull. 2000 PMID: 10706389
Ulukaya and Wood Fenretinide and its relation to cancer. Cancer Treat.Rev. 1999 PMID: 10448131
Le Doze Pharmacokinetics of all-trans retinoic acid, 13-cis retinoic acid, and fenretinide in plasma and brain of rat. Drug Metab.Dispos. 2000 PMID: 10640519

Fenretinide

Tocris Bioscience, part of Bio-Techne | Catalog # 1396

Key Product Details

Description

Alternative Names

View all Additional Retinoic Acid Receptor Compounds »

Product Description