5'-Fluoroindirubinoxime

Tocris Bioscience, part of Bio-Techne | Catalog # 4033

FLT3 inhibitor; displays antiproliferative activity
Discontinued Product
4033 has been discontinued. View all Flt-3 Inhibitors products.

Key Product Details

Description

FLT3 inhibitor; displays antiproliferative activity

View all Flt-3 Inhibitors »

Product Description

5'-Fluoroindirubinoxime is an inhibitor of FMS-like receptor tyrosine kinase-3 (FLT3) (IC50 = 15 nM). Displays selectivity for FLT3 against 6 other kinases including EGFR. Displays antiproliferative activity against the MV4;11 cell line (expressing constitutively active FLT3) and a number of cancer cell lines, including SNU-638 (stomach carcinoma) and HT-1080 (fibrosarcoma).

Licensing Information

Sold under licence from Anygen Co. Ltd.

Product Specifications

Molecular Weight

295.27

Formula

C16H10FN3O2

Storage

Store at +4°C

Purity

≥99% (HPLC)

Chemical Name

5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione 3-oxime

CAS Number

861214-33-7

PubChem ID

11580208

InChI Key

LBUXOYSDWHGJNP-UHFFFAOYSA-N

SMILES

O=C(NC4=C3C=C(F)C=C4)/C3=C2NC1=CC=CC=C1C/2=NO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.53 100

Preparing Stock Solutions for 5'-Fluoroindirubinoxime

The following data is based on the product molecular weight 295.27

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.39 mL 16.93 mL 33.87 mL
5 mM 0.68 mL 3.39 mL 6.77 mL
10 mM 0.34 mL 1.69 mL 3.39 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for 5'-Fluoroindirubinoxime

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for 5'-Fluoroindirubinoxime

For research use only

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