2'-MeCCPA

Name: 2'-MeCCPA
Brand: Tocris Bioscience
SKU: 2281

Tocris Bioscience, part of Bio-Techne | Catalog # 2281

Citations (10)

COA / SDS

Highly selective and potent A1 receptor agonist

Key Product Details

Description:	Highly selective and potent A₁ receptor agonist
Chemical Name:	2-Chloro-N-cyclopentyl-2'-methyladenosine
Purity:	≥98% (HPLC)
Molecular Weight:	383.83

View Full Technical Details for 2'-MeCCPA

Technical Data
Citations

Biological Activity for 2'-MeCCPA

2'-MeCCPA is a potent and highly selective agonist at A₁ adenosine receptors (K_i values are 3.3, 9580, 37600 and 1150 nM for human recombinant A₁, A_2A, A_2B and A₃ receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC₅₀ value of 13.1 nM.

Compound Libraries for 2'-MeCCPA

2'-MeCCPA is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for 2'-MeCCPA

M. Wt	383.83
Formula	C₁₆H₂₂ClN₅O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	205171-12-6
PubChem ID	10475082
InChi Key	MMPAUXMIDJWGFO-ROMFRFKVSA-N
Smiles	O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC3=C2N=C(Cl)N=C3NC4CCCC4)[C@@](C)1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 2'-MeCCPA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.6	25

Preparing Stock Solutions for 2'-MeCCPA

The following data is based on the product molecular weight 383.83.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.42 mL	52.11 mL	104.21 mL
1.25 mM	2.08 mL	10.42 mL	20.84 mL
2.5 mM	1.04 mL	5.21 mL	10.42 mL
12.5 mM	0.21 mL	1.04 mL	2.08 mL

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Reconstitution Calculator

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References for 2'-MeCCPA

References are publications that support the biological activity of the product.

Cappellacci Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. J.Med.Chem. 2005 PMID: 15743197
Franchetti 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. J.Med.Chem. 1998 PMID: 9572897