2'-MeCCPA
Tocris Bioscience, part of Bio-Techne | Catalog # 2281
Highly selective and potent A1 receptor agonist
Key Product Details
Description
Highly selective and potent A1 receptor agonist
Product Description
2'-MeCCPA is a potent and highly selective agonist at A1 adenosine receptors (Ki values are 3.3, 9580, 37600 and 1150 nM for human recombinant A1, A2A, A2B and A3 receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC50 value of 13.1 nM.Product Specifications
Molecular Weight
383.83
Formula
C16H22ClN5O4
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Chloro-N-cyclopentyl-2'-methyladenosine
CAS Number
205171-12-6
PubChem ID
10475082
InChI Key
MMPAUXMIDJWGFO-ROMFRFKVSA-N
SMILES
O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC3=C2N=C(Cl)N=C3NC4CCCC4)[C@@](C)1O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.6 | 25 |
Preparing Stock Solutions
for 2'-MeCCPA
The following data is based on the product molecular weight 383.83
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 10.42 mL | 52.11 mL | 104.21 mL |
| 1.25 mM | 2.08 mL | 10.42 mL | 20.84 mL |
| 2.5 mM | 1.04 mL | 5.21 mL | 10.42 mL |
| 12.5 mM | 0.21 mL | 1.04 mL | 2.08 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cappellacci Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. J.Med.Chem. 2005 PMID: 15743197
- Franchetti 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. J.Med.Chem. 1998 PMID: 9572897
Product Specific Notices for 2'-MeCCPA
For research use only
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