Recombinant Human IL-12 Protein
Catalog # 219-IL | R&D Systems, Inc. a Bio-Techne Brand
Bigger Scale, More Savings. Try our NEW version of Human Recombinant IL-12 (10018-IL). Combining R&D Systems quality with scalability that allows for lower price points and a solid supply chain.
Key Product Details
Source: | Sf 21 (baculovirus) |
Accession #: | P29460 (p40) & P29459 (p35) |
Structure / Form: | Disulfide-linked heterodimer |
Applications: | Bioactivity |
Citations for Recombinant Human IL-12 Protein (129)
Citations are publications that use Bio-Techne products. Selected citations for Recombinant Human IL-12 Protein include:
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Species: Human
Sample Types: Whole Cells
Applications: BioassayACH Szeto et al. (2022-12-22), An alphavbeta3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity Nature Immunology, 2022-124(1):123-135.
PMID: 36550322 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayE Cruz-Loren et al. (2022-10-18), Host Cell Redox Alterations Promote Latent HIV-1 Reactivation through Atypical Transcription Factor Cooperativity Viruses, 2022-114(10).
PMID: 36298843 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayYS Michaels et al. (2022-08-24), DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells Science Advances, 2022-08(34):eabn5522.
PMID: 36001668 -
Species: Human
Sample Types: Whole Cells
Applications: StimulationAKO Rode et al. (2022-08-19), Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor Cells, 2022-011(16).
PMID: 36010663 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureP Sekhri et al. (2022-03-11), The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma Cells Cancers, 2022-014(6).
PMID: 35326601 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayG Carbotti et al. (2021-08-09), IL-27 Mediates PD-L1 Expression and Release by Human Mesothelioma Cells Cancers, 2021-013(16).
PMID: 34439164 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayK Jamal Jame et al. (2021-07-02), Biomarkers for Comorbidities Modulate the Activity of T-Cells in COPD International Journal of Molecular Sciences, 2021-022(13).
PMID: 34281240 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Ogishi et al. (2021-06-28), Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child Nature Medicine, 2021-00(0).
PMID: 34183838 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayML Chen et al. (2021-04-07), CAR directs T cell adaptation to bile acids in the small intestine Nature, 2021-00(0).
PMID: 33828301 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayE Kidzeru et al. (2021-01-21), Myeloid-derived suppressor cells and their association with vaccine immunogenicity in South African infants Journal of leukocyte biology, 2021-00(0).
PMID: 33477200 -
Species: Rhesus Macaque
Sample Types: Whole Cells
Applications: BioassayS Watanabe et al. (2020-08-03), Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions J. Immunol., 2020-00(0).
PMID: 32747501 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Yan et al. (2020-06-30), T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Cell Rep, 2020-031(13):107820.
PMID: 32610123 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Zhu et al. (2020-06-11), Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In�Vivo Persistence and Enhances Anti-tumor Activity Cell Stem Cell, 2020-00(0).
PMID: 32531207 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMY Hsieh et al. (2020-05-29), Diminished toll-like receptor response in febrile infection-related epilepsy syndrome (FIRES) Biomed J, 2020-00(0).
PMID: 32651134 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureY Hu et al. (2020-03-19), Targeting of CD38 by the tumor suppressor miR-26a serves as a novel potential therapeutic agent in multiple myeloma Cancer Res., 2020-00(0).
PMID: 32193289 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureJU Shin et al. (2020-03-05), Recapitulating T cell infiltration in 3D psoriatic skin models for patient-specific drug testing Sci Rep, 2020-010(1):4123.
PMID: 32139717 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayUI Wu et al. (2019-11-28), Patients with Idiopathic Pulmonary Nontuberculous Mycobacterial Disease Have Normal Th1/Th2 Cytokine Responses but Diminished Th17 Cytokine and Enhanced Granulocyte-Macrophage Colony-Stimulating Factor Production Open Forum Infect Dis, 2019-16(12):ofz484.
PMID: 31807607 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayAC Pecher et al. (2019-10-15), Invariant natural killer T cells are functionally impaired in patients with systemic sclerosis Arthritis Res. Ther., 2019-121(1):212.
PMID: 31615552 -
Species: Human
Sample Types: Whole Blood
Applications: BioassayR Khoshnevis et al. (2019-09-20), IL-12Rbeta1 deficiency corresponding to concurrency of two diseases, mendelian susceptibility to mycobacterial disease and Crohn's disease J Clin Tuberc Other Mycobact Dis, 2019-017(0):100123.
PMID: 31788565 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Hofland et al. (2019-09-11), Dissection of the Effects of JAK and BTK Inhibitors on the Functionality of Healthy and Malignant Lymphocytes J. Immunol., 2019-00(0).
PMID: 31511358 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureH Wang et al. (2019-07-22), Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity Nat Commun, 2019-010(1):3254.
PMID: 31332184 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureJH Bernink et al. (2019-07-01), c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies Nat. Immunol., 2019-00(0).
PMID: 31263279 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJ Kristoff et al. (2019-04-02), Type 1-programmed dendritic cells drive antigen-specific latency reversal and immune elimination of persistent HIV-1 EBioMedicine, 2019-00(0).
PMID: 30952614 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Hochdörfer et al. (2019-03-28), Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells Eur. J. Immunol., 2019-00(0).
PMID: 30892687 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLD Uppendahl et al. (2019-01-15), Cytokine-induced memory-like natural killer cells have enhanced function, proliferation, and in vivo expansion against ovarian cancer cells Gynecol. Oncol., 2019-00(0).
PMID: 30658847 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayP Gruarin et al. (2018-11-29), Eomesodermin controls a unique differentiation program in human IL-10 and IFN-? co-producing regulatory T-cells Eur. J. Immunol., 2018-10(0).
PMID: 30431161 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayAA Throm et al. (2018-11-15), Dysregulated NK cell PLC?2 signaling and activity in juvenile dermatomyositis JCI Insight, 2018-13(22).
PMID: 30429375 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayV Lagou et al. (2018-10-16), Genetic Architecture of Adaptive Immune System Identifies Key Immune Regulators Cell Rep, 2018-125(3):798-810.e6.
PMID: 30332657 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJC Yu et al. (2018-09-06), Induction of antiinflammatory purinergic signaling in activated human iNKT cells JCI Insight, 2018-03(17).
PMID: 30185656 -
Species: Human
Sample Types: Complex Sample Type
Applications: BioassayP Garnier et al. (2018-05-10), The localisation of the heparin binding sites of human and murine interleukin-12 within the carboxyterminal domain of the P40 subunit Cytokine, 2018-0110(0):159-168.
PMID: 29753267 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Enerbäck et al. (2018-05-04), The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells Sci Rep, 2018-08(1):7043.
PMID: 29728633 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayQ Huang et al. (2018-04-08), Activated pancreatic stellate cells inhibit NK cell function in the human pancreatic cancer microenvironment Cell. Mol. Immunol., 2018-00(0).
PMID: 29628497 -
Species: Human
Sample Types: Whole Cells
Applications: Cell CultureKS Burrack et al. (2018-04-03), Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells Immunity, 2018-00(0).
PMID: 29625893 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayS Sugita et al. (2018-04-01), Natural Killer Cell Inhibition by HLA-E Molecules on Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelial Cells Invest. Ophthalmol. Vis. Sci., 2018-059(5):1719-1731.
PMID: 29610856 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMC Neidert et al. (2018-03-20), The natural HLA ligandome of glioblastoma stem-like cells: antigen discovery for T cell-based immunotherapy Acta Neuropathol., 2018-00(0).
PMID: 29557506 -
Species: Human
Sample Types: Whole Blood
Applications: BioassayJJ Gilchrist et al. (2018-03-09), Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4 Nat Commun, 2018-09(1):1014.
PMID: 29523850 -
Species: Human
Sample Types: Whole Blood
Applications: BioassayAW Clarke et al. (2018-03-05), An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease MAbs, 2018-00(0):1-43.
PMID: 29436901 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJG Chen et al. (2018-03-01), BTKCys481Serdrives ibrutinib resistance via ERK1/2, and protects BTKWild-TypeMYD88 mutated cells by a paracrine mechanism Blood, 2018-00(0).
PMID: 29496671 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayL Golden-Mas et al. (2018-03-01), Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment Hepatol Commun, 2018-02(4):364-375.
PMID: 29619416 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayT Oth et al. (2018-02-13), Pathogen recognition by NK cells amplifies the pro-inflammatory cytokine production of monocyte-derived DC via IFN-? BMC Immunol., 2018-019(1):8.
PMID: 29433450 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Felices et al. (2018-02-08), Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect JCI Insight, 2018-03(3).
PMID: 29415897 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayM Najar et al. (2018-01-19), Mesenchymal stromal cells of the bone marrow and natural killer cells: cell interactions and cross modulation J Cell Commun Signal, 2018-00(0).
PMID: 29350342 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Hijikata et al. (2018-01-02), A phase I clinical trial of RNF43 peptide-related immune cell therapy combined with low-dose cyclophosphamide in patients with advanced solid tumors PLoS ONE, 2018-013(1):e0187878.
PMID: 29293510 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayL Miao et al. (2017-11-21), Interleukin-12-mediated expression of matrix metalloproteinases in human periodontal ligament fibroblasts involves in NF-kappaB activation Biosci. Rep., 2017-10(0).
PMID: 29054963 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayE Briend et al. (2017-08-22), IL-18 associated with lung lymphoid aggregates drives IFN? production in severe COPD Respir. Res., 2017-018(1):159.
PMID: 28830544 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMS Longhi et al. (2017-05-04), Bilirubin suppresses Th17 immunity in colitis by upregulating CD39 JCI Insight, 2017-02(9).
PMID: 28469075 -
Species: Human
Sample Types: Whole Cells
S Lopez-Last et al. (2017-04-06), A functional DC cross talk promotes human ILC homeostasis in humanized mice Blood Adv, 2017-01(10):601-614.
PMID: 29296702 -
Species: Human
Sample Types: Whole Cells
A Camelo et al. (2017-03-30), IL-33, IL-25, and TSLP induce a distinct phenotypic and activation profile in human type 2 innate lymphoid cells Blood Adv, 2017-01(10):577-589.
PMID: 29296700 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayC Guntermann et al. (2017-03-09), Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations JCI Insight, 2017-02(5):e91127.
PMID: 28289717 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Tsukamoto et al. (2017-02-24), Soluble IL-6R expressed by myeloid cells reduces tumor-specific Th1 differentation and drives tumor progression Cancer Res, 2017-00(0).
PMID: 28235765 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayH Jensen et al. (2017-01-31), EBI3 regulates the NK cell response to mouse cytomegalovirus infection Proc. Natl. Acad. Sci. U.S.A, 2017-00(0).
PMID: 28143936 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayA Jud et al. (2017-01-24), Tonsillar CD56brightNKG2A+ NK cells restrict primary Epstein-Barr virus infection in B cells via IFN-? Oncotarget, 2017-08(4):6130-6141.
PMID: 28008151 -
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA (Control)(2016-12-07), Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML Mol Ther Methods Clin Dev, 2016-13(0):16074.
PMID: 27933304 -
Species: Human
Sample Types: Whole Cells
Applications: CAR-T (Bioassay)Roybal K et al. (2016-09-29), Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors. Cell, 2016-0167(2):419-432.e16.
PMID: 27693353 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayY Wang et al. (2016-09-19), Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations J. Exp. Med., 2016-0213(11):2413-2435.
PMID: 27647349 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayI de Weerdt et al. (2016-08-04), Innate lymphoid cells are expanded and functionally altered in chronic lymphocytic leukemia Haematologica, 2016-0101(11):e461-e464.
PMID: 27662009 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassay(2016-08-03), Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo PLoS Pathog, 2016-012(8):e1005788.
PMID: 27487232 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBurak Dura (2016-06-14), Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture Proc Natl Acad Sci USA, 2016-00(0).
PMID: 27303033 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySM Bal et al. (2016-04-25), IL-1?, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs Nat Immunol, 2016-00(0).
PMID: 27111145 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayChai S et al. (2015-11-04), Identification of Four-Jointed Box 1 (FJX1)-Specific Peptides for Immunotherapy of Nasopharyngeal Carcinoma. PLoS ONE, 2015-110(11):e0130464.
PMID: 26536470 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKudo H et al. (2015-09-09), EBI3 Downregulation Contributes to Type I Collagen Overexpression in Scleroderma Skin. J Immunol, 2015-0195(8):3565-73.
PMID: 26355156 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJacomet F et al. (2015-05-20), Evidence for eomesodermin-expressing innate-like CD8(+) KIR/NKG2A(+) T cells in human adults and cord blood samples. Eur J Immunol, 2015-045(7):1926-33.
PMID: 25903796 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHeinonen M et al. (2015-05-11), GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy. J Immunol, 2015-0194(12):5885-94.
PMID: 25964488 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWilson R et al. (2015-05-04), STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function. J Exp Med, 2015-0212(6):855-64.
PMID: 25941256 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRanzani et al. (2015-01-26), The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4. Nat Immunol, 2015-016(3):318-25.
PMID: 25621826 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySugita S et al. (2015-01-20), Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci, 2015-056(2):1051-62.
PMID: 25604685 -
Species: Human
Sample Types: Cell Culture Supernates
Applications: BioassayMoore C et al. (2014-12-10), Direct and indirect effects of immune and central nervous system-resident cells on human oligodendrocyte progenitor cell differentiation. J Immunol, 2014-1194(2):761-72.
PMID: 25505283 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMohnle P et al. (2014-11-27), MicroRNA-146a controls Th1-cell differentiation of human CD4+ T lymphocytes by targeting PRKCepsilon. Eur J Immunol, 2014-145(1):260-72.
PMID: 25308712 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayArber C et al. (2014-11-21), Survivin-specific T cell receptor targets tumor but not T cells. J Clin Invest, 2014-1125(1):157-68.
PMID: 25415440 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLam et al. (2014-11-04), Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy. Mol Ther, 2014-123(2):387-95.
PMID: 25366030 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKylaniemi M et al. (2014-07-14), The regulation and role of c-FLIP in human Th cell differentiation. PLoS ONE, 2014-09(7):e102022.
PMID: 25019384 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayDuhen T et al. (2014-06-02), IL-1beta promotes the differentiation of polyfunctional human CCR6+CXCR3+ Th1/17 cells that are specific for pathogenic and commensal microbes. J Immunol, 2014-0193(1):120-9.
PMID: 24890729 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTouzot M et al. (2014-05-28), Combinatorial flexibility of cytokine function during human T helper cell differentiation. Nat Commun, 2014-05(0):3987.
PMID: 24865484 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKofler D et al. (2014-05-08), Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest, 2014-0124(6):2513-22.
PMID: 24812667 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKongsbak M et al. (2014-05-02), Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. PLoS ONE, 2014-09(5):e96695.
PMID: 24792400 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayTeunissen M et al. (2014-03-21), Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients. J Invest Dermatol, 2014-0134(9):2351-60.
PMID: 24658504 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayZou Y et al. (2014-03-18), Manipulating the expression of chemokine receptors enhances delivery and activity of cytokine-induced killer cells. Br J Cancer, 2014-0110(8):1992-9.
PMID: 24642619 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayGresnigt M et al. (2014-03-06), A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist. PLoS Pathog, 2014-010(3):e1003936.
PMID: 24603878 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPrigent L et al. (2014-02-18), The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation. Eur J Immunol, 2014-044(5):1330-40.
PMID: 24549985 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMavropoulos A et al. (2014-02-03), Flow cytometric detection of p38 MAPK phosphorylation and intracellular cytokine expression in peripheral blood subpopulations from patients with autoimmune rheumatic diseases. J Immunol Res, 2014-02014(0):671431.
PMID: 24741615 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayReichwald K et al. (2014-01-08), TL1A induces TCR independent IL-6 and TNF-alpha production and growth of PLZF(+) leukocytes. PLoS ONE, 2014-09(1):e85793.
PMID: 24416448 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCheng X et al. (2014-01-01), High activities of BACE1 in brains with mild cognitive impairment. Am J Pathol, 2014-0184(1):141-7.
PMID: 24332014 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayPliyev B et al. (2013-12-16), Neutrophil microparticles modulate cytokine production by natural killer cells. Cytokine, 2013-165(2):126-9.
PMID: 24355430 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWang et al. (2013-09-27), Mapping the p53 transcriptome universe using p53 natural polymorphs. Cell Death Differ, 2013-021(4):521-32.
PMID: 24076587 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHawkins R et al. (2013-06-20), Global chromatin state analysis reveals lineage-specific enhancers during the initiation of human T helper 1 and T helper 2 cell polarization. Immunity, 2013-038(6):1271-84.
PMID: 23791644 -
Species: Mouse
Sample Types: Whole Cells
Applications: BioassayStephens G et al. (2013-05-08), Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands. Eur J Immunol, 2013-043(7):1727-34.
PMID: 23568529 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayChen et al. (2013-03-20), Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway. PLoS ONE, 2013-08(3):e59194.
PMID: 23527130 -
Species: Human
Sample Types: Plasma
Applications: BioassayRosen L et al. (2013-03-18), Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis. J Immunol, 2013-0190(8):3959-66.
PMID: 23509356 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWilk S et al. (2013-03-01), Adiponectin modulates NK-cell function. Eur J Immunol, 2013-043(4):1024-33.
PMID: 23401034 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayDong J et al. (2013-03-01), Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-gamma memory in human CD4(+) T lymphocytes. Eur J Immunol, 2013-043(3):793-804.
PMID: 23255246 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMazerolles F et al. (2013-02-10), Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency. J Allergy Clin Immunol, 2013-0131(4):1146-56, 1156.
PMID: 23403044 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayYou C et al. (2012-09-01), AAV2/IL-12 gene delivery into dendritic cells (DC) enhances CTL stimulation above other IL-12 applications: Evidence for IL-12 intracrine activity in DC. Oncoimmunology, 2012-01(6):847-855.
PMID: 23162752 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWilson TR et al. (2012-07-26), Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-0487(7408):505-9.
PMID: 22763448 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayFlanagan K et al. (2012-07-06), Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS. PLoS ONE, 2012-07(7):e40443.
PMID: 22792325 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayNielsen N et al. (2012-02-22), Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A. PLoS ONE, 2012-07(2):e31959.
PMID: 22384114 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayCarrier Y et al. (2011-09-01), Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis. J. Invest. Dermatol., 2011-0131(12):2428-37.
PMID: 21881584 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLe Garff-Tavernier M et al. (2010-10-26), Analysis of CD16+CD56dim NK cells from CLL patients: evidence supporting a therapeutic strategy with optimized anti-CD20 monoclonal antibodies. Leukemia, 2010-125(1):101-9.
PMID: 20975664 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRamirez JM et al. (2010-09-01), Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells. Eur. J. Immunol., 2010-040(9):2450-9.
PMID: 20706985 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBeziat V et al. (2010-08-06), NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs. PLoS ONE, 2010-05(8):e11966.
PMID: 20700504 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayJindra C (2010-02-01), Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. Eur J Immunol, 2010-040(2):321-9.
PMID: 19950173 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRamana Rao PV et al. (2010-01-01), Natural killer cell-mediated cytokine response among HIV-positive south Indians with pulmonary tuberculosis. J. Interferon Cytokine Res., 2010-030(1):33-42.
PMID: 20028198 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayReeves EP et al. (2009-12-21), IL-8 dictates glycosaminoglycan binding and stability of IL-18 in cystic fibrosis. J. Immunol., 2009-1184(3):1642-52.
PMID: 20026745 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBrucklacher-Waldert V et al. (2009-11-01), Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression. J. Immunol., 2009-1183(9):5494-501.
PMID: 19843935 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWitte K et al. (2009-10-01), Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun., 2009-110(8):702-14.
PMID: 19798076 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayDe Jager W et al. (2009-09-01), Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum., 2009-060(9):2782-93.
PMID: 19714583 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayEid RE et al. (2009-03-02), Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation, 2009-0119(10):1424-32.
PMID: 19255340 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayBeziat V et al. (2009-01-08), Fully functional NK cells after unrelated cord blood transplantation. Leukemia, 2009-023(4):721-8.
PMID: 19151772 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayLee WI et al. (2008-12-13), Immunologic analysis of HIV-uninfected Taiwanese children with BCG-induced disease. J. Clin. Immunol., 2008-129(3):319-29.
PMID: 19089604 -
Sample Types: N/A
Applications: ELISA (Standard)Biancotto A et al. (2008-03-01), Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo. AIDS Res. Hum. Retroviruses, 2008-024(3):453-62.
PMID: 18327985 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWu B et al. (2007-12-26), IL-24 modulates IFN-gamma expression in patients with tuberculosis. Immunol. Lett., 2007-1117(1):57-62.
PMID: 18199488 -
Sample Types: N/A
Applications: ELISA (Standard)Pfleger C et al. (2007-10-22), Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays. J. Immunol. Methods, 2007-1329(1):214-8.
PMID: 17964594 -
Species: Human
Sample Types: Whole Cells
Applications: Bioassayde Matos CT et al. (2007-05-22), Activating and inhibitory receptors on synovial fluid natural killer cells of arthritis patients: role of CD94/NKG2A in control of cytokine secretion. Immunology, 2007-0122(2):291-301.
PMID: 17521371 -
Sample Types: N/A
Applications: ELISA (Standard)Biancotto A et al. (2007-02-08), Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-0109(10):4272-9.
PMID: 17289812 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayEbert EC et al. (2006-08-17), Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription. Cell. Immunol., 2006-0241(1):7-13.
PMID: 16914126 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayGounni Abdelilah S et al. (2006-06-16), Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines. Clin. Immunol., 2006-0120(2):220-31.
PMID: 16782408 -
Sample Types: N/A
Applications: ELISA (Specificity Testing)Vaknin-Dembinsky A et al. (2006-06-15), IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J. Immunol., 2006-0176(12):7768-74.
PMID: 16751425 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayChapgier A et al. (2006-04-15), Human complete Stat-1 deficiency is associated with defective type I and II IFN responses in vitro but immunity to some low virulence viruses in vivo. J. Immunol., 2006-0176(8):5078-83.
PMID: 16585605 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayHanabuchi S et al. (2006-01-05), Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood, 2006-0107(9):3617-23.
PMID: 16397134 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayDulos J et al. (2005-03-01), CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum., 2005-052(3):770-8.
PMID: 15751070 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayRadstake TR et al. (2004-12-01), Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma. Arthritis Rheum., 2004-150(12):3856-65.
PMID: 15593217 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayKao CY et al. (2004-09-01), IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways. J. Immunol., 2004-0173(5):3482-91.
PMID: 15322213 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayFieschi C et al. (2004-06-03), A novel form of complete IL-12/IL-23 receptor beta1 deficiency with cell surface-expressed nonfunctional receptors. Blood, 2004-0104(7):2095-101.
PMID: 15178580 -
Species: Human
Sample Types: Whole Cells
Applications: BioassaySchmidt KN et al. (2004-01-01), APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNA. J. Immunol., 2004-0172(1):138-43.
PMID: 14688319 -
Sample Types: N/A
Applications: ELISA (Standard)Copeland S et al. (2004-01-01), Direct comparison of traditional ELISAs and membrane protein arrays for detection and quantification of human cytokines. J. Immunol. Methods, 2004-0284(1):99-106.
PMID: 14736420 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayMoreaux J et al. (2003-12-04), BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone. Blood, 2003-1103(8):3148-57.
PMID: 15070697 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayDurali D et al. (2003-07-31), In human B cells, IL-12 triggers a cascade of molecular events similar to Th1 commitment. Blood, 2003-0102(12):4084-9.
PMID: 12893768 -
Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
Sample Types: Whole Cells
Applications: BioassayFavre D et al. (2002-11-01), Lack of an immune response against the tetracycline-dependent transactivator correlates with long-term doxycycline-regulated transgene expression in nonhuman primates after intramuscular injection of recombinant adeno-associated virus. J. Virol., 2002-176(22):11605-11.
PMID: 12388721 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayParham C et al. (2002-06-01), A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol., 2002-0168(11):5699-708.
PMID: 12023369 -
Species: Human
Sample Types: Whole Cells
Applications: BioassayWolk K et al. (2002-06-01), Cutting edge: immune cells as sources and targets of the IL-10 family members? J. Immunol., 2002-0168(11):5397-402.
PMID: 12023331
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Customer Reviews for Recombinant Human IL-12 Protein (1)
FAQs for Recombinant Human IL-12 Protein
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What is the difference between Recombinant Human IL-12 Protein (Catalog # 219-IL) and Recombinant Human Il-12 (linked heterodimer) Protein (Catalog # 10018-IL?
The Recombinant Human IL-12 Protein (Catalog # 219-IL), expressed in Sf 21 cells, is a disulfide-linked homodimer consisting of the p35 and p40 subunits. The subunits can be separated under reducing conditions. The Recombinant Human IL-12 (linked heterodimer) Protein (Catalog # 10018-IL), expressed in HEK293 cells, is a chimeric protein consisting of the p35 and p40 subunits connected by a linker. These two subunits cannot be separated.
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Human IL-23 and Human IL-12 share a p40 subunit. Why is the predicted molecular weight for the p40 subunit 36.5 kDa in the Recombinant Human IL-23 Protein (Catalog # 1290-IL), while the predicted molecular weight for the p40 subunit is 34.7 kDa for the Recombinant Human IL-12 Protein (Catalog # 219-IL)?
The Recombinant Human IL-23 Protein (Catalog # 1290-IL) and Recombinant Human IL-12 Protein (Catalog # 219-IL) p40 subunits share the same p40 sequence, Ile23-Ser328 (Accession # P29460). However, the p40 subunit for Recombinant Human IL-23 (Catalog # 1290-IL) also contains a portion of the GS linker that remains after cleaving p40 subunit from the p19 subunit, so its predicted molecular is slightly larger (36.5 kDa) compared to that of the Recombinant Human IL-12 Protein (Catalog # 219-IL; 34.7 kDa). Please see the product-specific page for detailed sequence information.