Recombinant Human Bestrophin 1 His Protein
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-53038
Key Product Details
Source
E. coli
Tag
His
Conjugate
Unconjugated
Applications
SDS-PAGE
Product Specifications
Description
A denatured recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 292-585 of Human Bestrophin 1
Source: E.coli
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSEQLINPF GEDDDDFETN WIVDRNLQVS LLAVDEMHQD LPRMEPDMYW NKPEPQPPYT AASAQFRRAS FMGSTFNISL NKEEMEFQPN QEDEEDAHAG IIGRFLGLQS HDHHPPRANS RTKLLWPKRE SLLHEGLPKN HKAAKQNVRG QEDNKAWKLK AVDAFKSAPL YQRPGYYSAP QTPLSPTPMF FPLEPSAPSK LHSVTGIDTK DKSLKTVSSG AKKSFELLSE SDGALMEHPE VSQVRRKTVE FNLTDMPEIP ENHLKEPLEQ SPTNIHTTLK DHMDPYWALE NRDEAHS
Purity
>90%, by SDS-PAGE
Predicted Molecular Mass
36 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Application Notes
Denatured protein is most likely not the best option for functional studies. It is better suited for Western Blot (WB) or imaging assays.
Protein / Peptide Type
Recombinant Protein
Scientific Data Images for Recombinant Human Bestrophin 1 His Protein
![SDS-PAGE: Recombinant Human Bestrophin 1 His Protein [NBP2-53038]](https://resources.bio-techne.com/images/products/Recombinant Human Bestrophin 1 His Protein-SDS-Page-NBP2-53038-img0003.jpg "SDS-PAGE: Recombinant Human Bestrophin 1 His Protein [NBP2-53038]")
SDS-PAGE: Recombinant Human Bestrophin 1 His Protein [NBP2-53038]
SDS-Page: Recombinant Human Bestrophin 1 His Protein [NBP2-53038] - 3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain.Formulation, Preparation and Storage
NBP2-53038
| Formulation | 20 mM Tris-HCl buffer (pH 8.0), 0.4M UREA, 10% glycerol |
| Preservative | No Preservative |
| Concentration | 1 mg/ml |
| Shipping | The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Background: Bestrophin 1
Bestrophin-1, also known as best macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an inherited autosomal form of macular degeneration, characterized by a depressed light peak in the electrooculogram (EOG). Bestrophin 1 is a 68 kDa basolateral plasma membrane protein encoded by the VMD2 gene. Bestrophin 1's function is still unknown, but data suggests that it is a chloride channel that plays a role in generating the altered EOG in Best disease patients. In addition, Bestrophin-1 is a useful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells.
Bestrophin antibodies are useful tools for studies involving vision and retinal disease. .
Alternate Names
ARB, BEST, Best disease, bestrophin 1, bestrophin-1, BMD, TU15B, vitelliform macular dystrophy 2, Vitelliform macular dystrophy protein 2, VMD2RP50
Gene Symbol
BEST1
Additional Bestrophin 1 Products
Product Documents for Recombinant Human Bestrophin 1 His Protein
Product Specific Notices for Recombinant Human Bestrophin 1 His Protein
This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.
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