Deazaflavin, Haloalkane
Tocris Bioscience, part of Bio-Techne | Catalog # 8987
Photosensitizer for proximity labeling experiments, NHS reactive group
Key Product Details
Description
Photosensitizer for proximity labeling experiments, NHS reactive group
Product Description
Deazaflavin, Haloalkane is a deazaflavin-based organic photocatalyst covalently linked to a chloroalkane ligand via a short PEG linker. The conjugate enables site-specific tethering of the photocatalyst to proteins genetically fused to HaloTag® in live-cell systems.Upon blue light illumination (~450 nm), the deazaflavin moiety transfers energy to nearby photoactivatable probes (e.g., diazirines, aryl azides), initiating localized covalent labeling of biomolecules in the immediate vicinity of the HaloTag® fusion protein. The process is dependent on light exposure, the presence of the reactive probe, and spatial proximity to the tethered photocatalyst.
Deazaflavin, Haloalkane is designed for use in photoproximity labeling experiments that aim to study protein interactions or spatial proteomics in live mammalian cells under mild illumination conditions without the use of metal-based photocatalysts.
HaloTag® is a registered trademark of Promega Corporation.
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Product Specifications
Molecular Weight
490.99
Formula
C24H31ClN4O5
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
N-(2-(2-((6-Chlorohexyl)oxy)ethoxy)ethyl)-2-(10-methyl-2,4-dioxo-4,10-dihydropyrimido[4,5-b]quinolin-3(2H)-yl)acetamide
InChI Key
CFRUFYBIYIESMB-UHFFFAOYSA-N
SMILES
O=C1N(C(C2=CC3=CC=CC=C3N(C2=N1)C)=O)CC(NCCOCCOCCCCCCCl)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.91 | 10 |
Preparing Stock Solutions
for Deazaflavin, Haloalkane
The following data is based on the product molecular weight 490.99
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.37 mL | 101.84 mL | 203.67 mL |
| 0.5 mM | 4.07 mL | 20.37 mL | 40.73 mL |
| 1 mM | 2.04 mL | 10.18 mL | 20.37 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.07 mL |
Calculators
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Background References
References are publications that support the biological activity of the product.
- Crocker Energy-transfer photoproximity labelling in live cells using an organic cofactor. Nat.Chem. 2025 PMID: 40962911
Product Specific Notices for Deazaflavin, Haloalkane
For research use only
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