Human Siglec-8 (NP_055257) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC1496
Key Product Details
Species
Human
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: Siglec-8
Siglec-8, also known as SAF, is a transmembrane lectin that is expressed on eosinophils, basophils, and mast cells and shows a binding preference for the carbohydrate 6-O sulfated sLe(x). The functional paralog of human Siglec-8 is known as Siglec-F in mouse. Cross-linking of Siglec-8 inhibits Fc epsilon RI alpha induced mast cell degranulation. It also induces eosinophil apoptosis, an effect which is enhanced by the eosinophil-activating cytokines IL-5, IL-33, and GM-CSF.
Long Name
Sialic Acid Binding Ig-like Lectin 8
Alternate Names
SAF2, Siglec8, SIGLEC8L
Entrez Gene IDs
27181 (Human)
Gene Symbol
SIGLEC8
UniProt
Additional Siglec-8 Products
Product Documents for Human Siglec-8 (NP_055257) VersaClone cDNA
Product Specific Notices for Human Siglec-8 (NP_055257) VersaClone cDNA
For research use only
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