Human MDR1/ABCB1 (AAA59576) VersaClone cDNA

R&D Systems, part of Bio-Techne | Catalog # RDC0891

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Key Product Details

Species

Human

Accession Number

AAA59576

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: MDR1/ABCB1

MDR1 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). MDR1 is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. (provided by RefSeq)

Long Name

ATP-binding Cassette, Sub-family B (MDR/TAP), Member 1B

Alternate Names

ABC20, ABCB1, ABCB1B, CD243, CLCS, GP170, IBD13, PGY1

Entrez Gene IDs

5243 (Human); 18669 (Mouse); 24646 (Rat)

Gene Symbol

ABCB1

UniProt

AAA59576

Additional MDR1/ABCB1 Products

Product Documents for Human MDR1/ABCB1 (AAA59576) VersaClone cDNA

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Human MDR1/ABCB1 (AAA59576) VersaClone cDNA

For research use only

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