Cynomolgus Monkey CTLA-4 (XP_005574071) VersaClone cDNA
R&D Systems, part of Bio-Techne | Catalog # RDC1693
Key Product Details
Species
Cynomolgus Monkey
Accession Number
Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: CTLA-4
CTLA-4/CD152 (Cytotoxic T-Lymphocyte Antigen 4) is a transmembrane T cell inhibitory molecule that is expressed as a covalent homodimer. CTLA-4 is recruited from intracellular vesicles to the immunological synapse beginning 1-2 days after T cell activation. It forms a linear lattice with B7-1 on APC, inducing negative regulatory signals and ending CD28-dependent T cell activation. Mice deleted for CTLA-4 develop lethal autoimmune reactions due to continued T cell activation and poor control by regulatory T cells which constitutively express CTLA-4.
Long Name
Cytotoxic T-lymphocyte-associated Molecule 4
Alternate Names
CD152, CTLA4
Gene Symbol
CTLA4
UniProt
Additional CTLA-4 Products
Product Documents for Cynomolgus Monkey CTLA-4 (XP_005574071) VersaClone cDNA
Product Specific Notices for Cynomolgus Monkey CTLA-4 (XP_005574071) VersaClone cDNA
For research use only
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