Thymidine Kinase 2 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-47480

Novus Biologicals, part of Bio-Techne
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NBP3-47480
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Key Product Details

Species Reactivity

Mouse, Rat

Applications

Immunohistochemistry, Western Blot, ELISA

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Thymidine Kinase 2 Antibodies »

Product Specifications

Immunogen

thymidine kinase 2, mitochondrial. (Uniprot# O00142)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

35 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

Novus Biologicals Rabbit Thymidine Kinase 2 Antibody - BSA Free (NBP3-47480) is a polyclonal antibody validated for use in IHC, WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for Thymidine Kinase 2 Antibody - BSA Free

Thymidine Kinase 2 Antibody - BSA Free

Immunohistochemistry: Thymidine Kinase 2 Antibody - BSA Free [NBP3-47480] -

Immunohistochemistry: Thymidine Kinase 2 Antibody - BSA Free [NBP3-47480] - Immunohistochemistry of paraffin-embedded rat kidney tissue slide using (Thymidine Kinase 2 Antibody) at dilution of 1:100
Thymidine Kinase 2 Antibody - BSA Free

Western Blot: Thymidine Kinase 2 Antibody - BSA Free [NBP3-47480] -

Western Blot: Thymidine Kinase 2 Antibody - BSA Free [NBP3-47480] - Mouse liver were subjected to SDS PAGE followed by western blot with (Thymidine Kinase 2 antibody) at dilution of 1:1000

Applications for Thymidine Kinase 2 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:50-1:500

Western Blot

1:200-1:2000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS, 50% Glycerol, pH (7.3)

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Thymidine Kinase 2

The mitochondrial deoxyribonucleotide (dNTP) pool is separated from the cytosolic pool because the mitochondria inner membrane is impermeable to charged molecules. The mitochondrial pool is maintained by either import of cytosolic dNTPs through dedicated transporters or by salvaging deoxynucleosides within the mitochondria; apparently, enzymes of the de novo dNTP synthesis pathway are not present in the mitochondria. In nonreplicating cells, where cytosolic dNTP synthesis is downregulated, mtDNA synthesis depends solely on the mitochondrial salvage pathway enzymes, the deoxyribonucleoside kinases. Two of the 4 human deoxyribonucleoside kinases, deoxyguanosine kinase (DGK) and thymidine kinase-2, are expressed in mitochondria. Human DGK, encoded by the DGUOK gene (MIM 601465), efficiently phosphorylates deoxyguanosine and deoxyadenosine, whereas TK2 phosphorylates deoxythymidine, deoxycytidine, and deoxyuridine. Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs.[supplied by OMIM]

Alternate Names

EC 2.7.1.21, MTDPS2, MTTK, mt-TK, thymidine kinase 2, mitochondrial

Gene Symbol

TK2

Additional Thymidine Kinase 2 Products

Product Documents for Thymidine Kinase 2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Thymidine Kinase 2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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