TGF-beta Antibody (TGFB/510) [Alexa Fluor™ Plus 647]
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08739AFP647
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Human, Mouse, Rat, Bovine, Canine, Hamster, Monkey
Applications
ELISA, Functional Assay
Label
Alexa Fluor Plus 647
Antibody Source
Monoclonal Mouse IgG1 kappa Clone # TGFB/510
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
Full length recombinant human TGF-beta protein
Localization
Cytoplasm and extracellular (secreted)
Specificity
This monoclonal antibody recognizes TGF beta 1, 2 and 3. TGFs inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells. Most breast lesions, benign and malignant, involve abnormal proliferation and altered architecture of stromal and/or epithelial elements.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1 kappa
Applications for TGF-beta Antibody (TGFB/510) [Alexa Fluor™ Plus 647]
Application
Recommended Usage
ELISA
Optimal dilutions of this antibody should be experimentally determined.
Functional Assay
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: TGF-beta
TGF-beta 1 (Transforming Growth Factor beta 1) is a pleiotrophic cytokine that regulates immune function, proliferation, and epithelial-mesenchymal transition. TGF-beta 1 associates with LAP to form a latent complex. It can be is activated from latency by plasmin, matrix metalloproteases, thrombospondin 1, and a subset of integrins. TGF-beta 1 signals through complexes of TGF-beta RII with TGF-beta RI/ALK-5 or ALK-1. TGF-beta signaling is modulated by the accessory receptors TGF-beta RIII/Betaglycan and Endoglin/CD105.
Long Name
Transforming Growth Factor beta
Alternate Names
TGFbeta
Gene Symbol
TGFB1
Additional TGF-beta Products
Product Documents for TGF-beta Antibody (TGFB/510) [Alexa Fluor™ Plus 647]
Product Specific Notices for TGF-beta Antibody (TGFB/510) [Alexa Fluor™ Plus 647]
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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