STAT5B is encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Long Name

Signal Transducer and Activator of Transcription 5b

Alternate Names

signal transducer and activator of transcription 5B, STAT5, transcription factor STAT5B

Gene Symbol

STAT5B

Additional STAT5b Products

Product Documents for STAT5b Antibody (1032E) [HRP]

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices for STAT5b Antibody (1032E) [HRP]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

STAT5b Antibody (1032E) [HRP]

Novus Biologicals, part of Bio-Techne | Catalog # FAB15841H

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

Concentration

View all STAT5b Antibodies »

Product Specifications

Immunogen

Specificity

Clonality

Host

Isotype

Applications for STAT5b Antibody (1032E) [HRP]

Immunocytochemistry

Immunoprecipitation

Knockout Validated

Western Blot

Formulation, Preparation, and Storage

Purification

Formulation

Preservative

Concentration

Shipping

Stability & Storage

Background: STAT5b