SIRP alpha/CD172a Antibody (S04-7G6)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19772

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19772-100ul
NBP3-19772-50ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S04-7G6 expressed in HEK293

Concentration

0.3 mg/ml

View all SIRP alpha/CD172a Antibodies »

Product Specifications

Immunogen

Recombinant protein of human SIRP alpha/CD172a (Uniprot # P78324)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

85 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

Novus Biologicals Rabbit SIRP alpha/CD172a Antibody (S04-7G6) (NBP3-19772) is a recombinant monoclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.

Scientific Data Images for SIRP alpha/CD172a Antibody (S04-7G6)

Western Blot: SIRP alpha/CD172a Antibody (S04-7G6) [NBP3-19772]

Western Blot: SIRP alpha/CD172a Antibody (S04-7G6) [NBP3-19772]

Western Blot: SIRP alpha/CD172a Antibody (S04-7G6) [NBP3-19772] - Western blot detection of SIRP alpha/CD172a in Rat Brain lysates using NBP3-19772 (1:1000 diluted). Predicted band size: 55kDa. Observed band size: 85kDa.

Applications for SIRP alpha/CD172a Antibody (S04-7G6)

Application
Recommended Usage

Western Blot

1/1000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SIRP alpha/CD172a

Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa (1), SHPS-1 (2,3), MyD-1 (4), BIT (5,6) and p84 (7). SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2 (1,2,5,8). SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes (1,2,5,8).

Long Name

Signal-regulatory Protein alpha

Alternate Names

BIT, CD172a, MFR, MYD-1, SHPS1, SIRPA

Gene Symbol

SIRPA

Additional SIRP alpha/CD172a Products

Product Documents for SIRP alpha/CD172a Antibody (S04-7G6)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for SIRP alpha/CD172a Antibody (S04-7G6)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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