Key Product Details

Species Reactivity

Mouse

Applications

Western Blot

Label

Biotin

Antibody Source

Monoclonal Rat IgG2A Clone # 377407

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PRDC/GREM2 Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant mouse PRDC/GREM2
Arg22-Gln168
Accession # O88273

Specificity

Detects mouse PRDC/GREM2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant mouse (rm) DAN, rmCerberus, rmGremlin, or rmCoco is observed.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2A

Description

This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.

For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.

Applications for PRDC/GREM2 Antibody (377407) [Biotin]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Recommended applications are based on validated applications from the unconjugated base product MAB2069. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: PRDC/GREM2

GREM2, also known as Gremlin-2, is a 168 amino acid that is 19 kDa, belongs to the DAN family, plays a role in the inhibition of the activity of BMP2 and BMP4 in a dose-dependent manner, and as an antagonist of BMP, it may play a role in regulating organogenesis, body patterning, and tissue differentiation. Current research is being performed on several diseases and disorders including astigmatism, myopia, accommodative esotropia, keratoconus, intraocular retinoblastoma, scimitar syndrome, swine influenza, influenza, norrie disease, and multiple sclerosis. The GREM2 protein is known to have an interaction with BMP4, BMP2, CER1, NOG, and FSTL1 in signal transduction and signaling by BMP pathways.

Long Name

Protein Related to DAN and Cerberus/Gremlin-2

Alternate Names

CKTSF1B2, DAND3, GREM2

Gene Symbol

GREM2

Additional PRDC/GREM2 Products

Product Documents for PRDC/GREM2 Antibody (377407) [Biotin]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for PRDC/GREM2 Antibody (377407) [Biotin]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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