Key Product Details

Species Reactivity

Human, Mouse

Applications

Label

Janelia Fluor 525

Antibody Source

Monoclonal Mouse IgG1 Clone # 469832

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all PKC beta 2 Antibodies »

Product Specifications

Immunogen

E. coli-derived recombinant human PKC beta2
Lys607-Ser673
Accession # P05771-2

Specificity

Detects endogenous human and mouse PKC beta2 in Western blots.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: PKC beta 2

Members of the Protein Kinase C (PKC) family are serine/threonine protein kinases that play a key regulatory role in a number of cellular functions including cell growth and differentiation, hormone secretion, and gene expression. Multiple genes and alternative splicing result in three subfamilies, which differ in their co-factor requirements: conventional PKC isoforms (alpha, beta 1, beta 2, and gamma) which require calcium and phosphatidylserine (PS), diacylglycerol (DAG) or phorbol esters for activation; novel isoforms (delta, epsilon, eta, and theta), which are calcium-independent but are still regulated by PS, DAG, or phorbol esters; and atypical isoforms (iota/lambda and zeta), which are calcium-independent and do not require PS, DAG, or phorbol esters for activation. PKC beta 2 regulation of c-myc expression has been shown to suppress insulin gene transcription in pancreatic beta-cells implicating PKC beta 2 for some of the beta-cell glucose toxicity found in diabetes.

Long Name

Protein Kinase C beta 2

Alternate Names

PKCB;PKCbeta;PKC-beta;PKCI(2);PRKCB;PRKCB1;PRKCB2;Protein kinase C beta type

Gene Symbol

PRKCB

Additional PKC beta 2 Products

Product Documents for PKC beta 2 Antibody (469832) [Janelia Fluor® 525]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for PKC beta 2 Antibody (469832) [Janelia Fluor® 525]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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