PDE6H Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-68659

Novus Biologicals, part of Bio-Techne
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NBP2-68659
NBP2-68659-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Monkey

Cited:

Primate - Macaca mulatta (Rhesus Macaque)

Predicted:

Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin

Cited:

Immunohistochemistry-Frozen

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all PDE6H Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: PRKGPPKFKQRQTRQFKSKPPKKGVKGFGDDIPGMEGLGTDITVICPWEAFSHLELHELA

Reactivity Notes

Use in Monkey reported in scientific literature (PMID:35024589) .

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PDE6H Antibody - BSA Free

PDE6H Antibody

Immunohistochemistry-Paraffin: PDE6H Antibody [NBP2-68659] -

Immunohistochemistry-Paraffin: PDE6H Antibody [NBP2-68659] - Staining of human eye, retina shows strong cytoplasmic positivity in photoreceptor cells.
PDE6H Antibody

Immunohistochemistry-Paraffin: PDE6H Antibody [NBP2-68659] -

Immunohistochemistry-Paraffin: PDE6H Antibody [NBP2-68659] - Staining of human stomach shows moderate cytoplasmic positivity in glandular cells.
PDE6H Antibody

Immunohistochemistry-Paraffin: PDE6H Antibody [NBP2-68659] -

Immunohistochemistry-Paraffin: PDE6H Antibody [NBP2-68659] - Staining of human kidney shows no positivity in cells in tubules and cells in glomeruli as expected.
View 1 more images

Applications for PDE6H Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:5000 - 1:10000

Immunohistochemistry-Frozen

Reported in scientific literature (PMID:35024589)

Immunohistochemistry-Paraffin

1:5000 - 1:10000
Application Notes
Recommended conditions for IHC,Retrieval method: HIER pH6.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: PDE6H

Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain. The process of converting light into an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. Photoexcitation of rhodopsin causes the cytoplasmic surface of the protein to become catalytically active. In the active state, rhodopsin activates transducin, a GTP binding protein. Once activated, transducin promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentration causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin activity is believed to be shut off by phosphorylation followed by binding of the soluble protein, arrestin. Transducin, once activated by rhodopsin, promotes the hydrolysis of cGMP by PDE. The subunit composition of transducin differs between different photoreceptor cells. Rod transducin consists of rod transducin alpha (Tr alpha), T beta, and T gamma. Cone transducin is composed of cone transducin alpha (Tc alpha), T beta and T gamma. Differential transducin subunit composition of transducin is believed to be responsible for the different light sensitivities between photoreceptive cells.

Long Name

Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma

Alternate Names

EC 3.1.4.17, EC 3.1.4.35, GMP-PDE gamma, phosphodiesterase 6H, cGMP-specific, cone, gamma, RCD3, retinal cone rhodopsin-sensitive cGMP 3'-5'-cyclic phosphodiesterase subunitgamma

Gene Symbol

PDE6H

Additional PDE6H Products

Product Documents for PDE6H Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for PDE6H Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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