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PAK4+5+6 [p Ser474, p Ser560, p Ser602] Antibody (2D1) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15234

Recombinant monoclonal antibody expressed in HEK293F cells
Novus Biologicals, part of Bio-Techne
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NBP3-15234

Key Product Details

Validated by

Biological Validation

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 2D1

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

A synthesized peptide derived from human Phospho-PAK4+5+6 (S474/S560/S602). UniProt (O96013/Q9P286/Q9NQU5).

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for PAK4+5+6 [p Ser474, p Ser560, p Ser602] Antibody (2D1) - BSA Free

Western Blot: PAK4+5+6 [p Ser474, p Ser560, p Ser602] Antibody (2D1) [NBP3-15234] - Positive WB detected in 293 whole cell lysate (treated with Calyculin A or not). All lanes PAK4+5+6 antibody at 2.15ug/ml. Secondary: Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 64,75,80 KDa. Observed band size: 75,80 Kda.
Immunocytochemistry/Immunofluorescence: PAK4+5+6 [p Ser474, p Ser560, p Ser602] Antibody (2D1) [NBP3-15234] - Immunofluorescence staining of HepG2 cells (treated with 50mM Calyculin A for 30 minutes) with at PAK4+5+6 antibody 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated Goat Anti-Rabbit IgG (H+L).

Applications for PAK4+5+6 [p Ser474, p Ser560, p Ser602] Antibody (2D1) - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:20-1:200

Western Blot

1:500-1:5000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, and 50% glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -70C. Avoid freeze-thaw cycles.

Background: PAK4+5+6

Three recently identified isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gammaPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiaekinase STE20, involved in pheromone signaling. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates. One such putative substrate is MEK kinase, an upstream effector of MEK4 which is involved in the JNK signaling pathway. While the PAK isoforms interact in a GTP-dependent manner with Rac1 and Cdc42, they do not interact with Rho.

Alternate Names

EC 2.7.11, EC 2.7.11.1, KIAA1142, p21 protein (Cdc42/Rac)-activated kinase 4, p21(CDKN1A)-activated kinase 4, p21-activated kinase 4, PAK-4, protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs, serine/threonine-protein kinase PAK 4

Gene Symbol

PAK4

Additional PAK4+5+6 Products

Product Documents for PAK4+5+6 [p Ser474, p Ser560, p Ser602] Antibody (2D1) - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for PAK4+5+6 [p Ser474, p Ser560, p Ser602] Antibody (2D1) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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