Mouse Serpin B8/Proteinase Inhibitor 8 Antibody
R&D Systems, part of Bio-Techne | Catalog # AF3588
Conjugate
Catalog #
Key Product Details
Species Reactivity
Mouse
Applications
Immunoprecipitation, Western Blot
Label
Unconjugated
Antibody Source
Polyclonal Goat IgG
Product Specifications
Immunogen
S. frugiperda insect ovarian cell line Sf 21-derived recombinant mouse Serpin B8/Proteinase Inhibitor 8
Asp2-Pro374
Accession # O08800
Asp2-Pro374
Accession # O08800
Specificity
Detects mouse Serpin B8/Proteinase Inhibitor 8 in direct ELISAs and Western blots. In Western blots, approximately 10% cross-reactivity with recombinant human (rh) Serpin B8, rhSerpin B9, and rhSerpin B6 is observed and less than 1% cross-reactivity with rhSerpin A1, D1, E2, I2, recombinant mouse Serpin A1, C1, E1, F1, and F2 is observed.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications for Mouse Serpin B8/Proteinase Inhibitor 8 Antibody
Application
Recommended Usage
Immunoprecipitation
25 µg/mL
Sample: Conditioned cell culture medium spiked with Recombinant Mouse Serpin B8/Proteinase Inhibitor 8, see our available Western blot detection antibodies
Sample: Conditioned cell culture medium spiked with Recombinant Mouse Serpin B8/Proteinase Inhibitor 8, see our available Western blot detection antibodies
Western Blot
0.1 µg/mL
Sample: Recombinant Mouse Serpin B8/Proteinase Inhibitor 8
Sample: Recombinant Mouse Serpin B8/Proteinase Inhibitor 8
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Serpin B8/Proteinase Inhibitor 8
Serpin B8, also known as Proteinase Inhibitor 8 (PI8) and cytoplasmic antiproteinase 2 (CAP2), is a member of the Serpin superfamily of the serine protease inhibitors (1). It inhibits furin, a ubiquitously expressed convertase that processes many pro-proteins (2). Distribution of Serpin B8 alters during kidney regeneration, indicating that it plays a role in inflammation or tissue repair (3).
References
- Silverman, G.A. et al. (2001) J. Biol. Chem. 276:33293.
- Dahlen, J.R. et al. (1998) J. Biol. Chem. 273:1851.
- Gillard, A. (2006) Am. J. Nephrol. 26:34. .
Alternate Names
CAP2, NK10, PI8
Gene Symbol
SERPINB8
UniProt
Additional Serpin B8/Proteinase Inhibitor 8 Products
Product Documents for Mouse Serpin B8/Proteinase Inhibitor 8 Antibody
Product Specific Notices for Mouse Serpin B8/Proteinase Inhibitor 8 Antibody
For research use only
Loading...
Loading...
Loading...
Loading...