Mouse CD11b/Integrin alpha M Fluorescein-conjugated Antibody

The Integrin family proteins are heterodimeric transmembrane receptors composed of an alpha and a beta subunit. The Integrin  alphaM subunit, also known as MAC-1 alpha subunit or CD11b, combines with the Integrin  beta2 subunit (CD18) to form the non-covalent heterodimer Integrin  alphaM/ beta2, also known as MAC-1 and Complement Receptor type 3 (CR3). Integrin  alphaM/ beta2 is expressed on granulocytes, macrophages, dendritic cells and natural killer cells. Upon activation, alphaM/ beta2 can bind several ligands (including ICAM-1, Fibrinogen, and the C3 Complement Fragment, C3bi) to mediate phagocyte adhesion, migration and ingestion of complement-opsonized particles.