Ly-6A/E Antibody (24GB370)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-50526

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NBP3-50526-100ul
NBP3-50526-20ul
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Mouse

Applications

Western Blot, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB370

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Ly-6A/E Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from mouse LLy-6A/E (Uniprot: P05533)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Applications for Ly-6A/E Antibody (24GB370)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Ly-6A/E

Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. (1-3) It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. (4-6) In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes, whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes. (1, 7-9) The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. (1, 8, 9) Studies with MAb D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses, (9-12) and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation. (3, 13)

Alternate Names

Ly 6A/E, Ly6A.2, Ly6A/E, Ly6E.1, Lymphocyte antigen 6 complex locus A, Lymphocyte antigen 6 complex locus E, Retinoic acid induced gene E, RIGE, SCA1, SCA-1, SCA2, Stem cell antigen 1, Stem cell antigen 2, T cell activating protein, TAP, Thymic shared antigen 1, TSA1

Gene Symbol

LY6A

Additional Ly-6A/E Products

Product Documents for Ly-6A/E Antibody (24GB370)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Ly-6A/E Antibody (24GB370)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.