Integrin beta 3/CD61 Antibody (ITGB3/3126R)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-48915

Recombinant Monoclonal Antibody
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NBP3-48915-100ug
NBP3-48915-20ug
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # ITGB3/3126R expressed in HEK293

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Integrin beta 3/CD61 Antibodies »

Product Specifications

Immunogen

Recombinant human ITGB3 protein fragment (aa 385-490) (exact sequence is proprietary) (Uniprot: P05106)

Localization

Cell junction, Cell membrane, Cell projection, Focal adhesion, Lamellipodium membrane, Postsynaptic cell membrane, Synapse

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Description

Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Antibody with azide - store at 2 to 8 C. Antibody without azide - store at -20 to -80 C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Scientific Data Images for Integrin beta 3/CD61 Antibody (ITGB3/3126R)

Integrin beta 3/CD61 Antibody (ITGB3/3126R)

Immunohistochemistry-Paraffin: Integrin beta 3/CD61 Antibody (ITGB3/3126R) [NBP3-48915] -

Formalin-fixed, paraffin-embedded human Spleen stained with Integrin beta 3/CD61 Antibody (ITGB3/3126R).

Applications for Integrin beta 3/CD61 Antibody (ITGB3/3126R)

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Integrin beta 3/CD61

Platelet membrane glycoprotein Integrin beta-3 (GP IIIa) forms a Ca2+-dependent heterodimer complex with GP IIb. The GP IIb-IIIa complex constitutes the fibrinogen and fibronectin receptor on stimulated platelets. A biochemically and immunologically similar membrane glycoprotein complex is present on endothelial cells. Homology suggests that GP IIIa is a member of a family of cell-surface adhesion receptors. (1) Data provide further support for the key role of the cytoplasmic domain of the beta3 integrin in cell adhesion and suggest a potential role for the beta3C integrin subunit in modulating cell-matrix interactions (2). It has been demonstrated that the beta 3 subunit of alpha IIb beta 3 was phosphorylated on tyrosine residues in response to thrombin-induced platelet aggregation. Data suggest that tyrosine phosphorylation of an integrin beta subunit may be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin (3). be important in initiating outside-in signaling cascades by inducing association of signaling components directly with the integrin (3).

Alternate Names

CD61, GP3A, GPIIIA, INGRB3, ITGB3

Gene Symbol

ITGB3

Additional Integrin beta 3/CD61 Products

Product Documents for Integrin beta 3/CD61 Antibody (ITGB3/3126R)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Integrin beta 3/CD61 Antibody (ITGB3/3126R)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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