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Integrin alpha 2b beta 3 Antibody (10E5) [Alexa Fluor® 350]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-81080AF350

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Alexa Fluor 350 (Excitation = 346 nm, Emission = 442 nm)

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # 10E5

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

Human blood platelets.

Specificity

The antibody binds to Integrin alpha 2b beta 3 with an affinity (Kd) of 16.2+-6 nM. The antibody completely inhibits platelet aggregation at 7.8 ug/ml.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Applications for Integrin alpha 2b beta 3 Antibody (10E5) [Alexa Fluor® 350]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Integrin alpha 2b beta 3

Integrin alpha 2b beta 3, also known as GPIIbIIIa, is the most abundant Integrin expressed by megakaryocytes and platelets, both on the surface and within alpha granules. Deficiencies of alpha 2b beta 3 produce Glanzmann thrombasthenia, a potentially serious bleeding disorder. Active cell surface alpha 2b beta 3 adheres to Fibrinogen, mediating platelet/platelet interactions that initiate a cascade of platelet activation and aggregation, extracellular matrix adhesion, formation of thrombi, and clot retraction. It also binds matrix proteins that have an RGD motif, including Fibronectin, Plasminogen, Prothrombin, Thrombospondin, and Vitronectin.

 

Alternate Names

BDPLT16;BDPLT2;CD41;CD41B;GP2B;GPIIb;GT;GT1;GTA;HPA3;Integrin alpha-IIb;ITGA2B;PPP1R93

Gene Symbol

ITGA2B

Additional Integrin alpha 2b beta 3 Products

Product Documents for Integrin alpha 2b beta 3 Antibody (10E5) [Alexa Fluor® 350]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Integrin alpha 2b beta 3 Antibody (10E5) [Alexa Fluor® 350]



Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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