Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

PE (Excitation = 488 nm, Emission = 575 nm)

Antibody Source

Polyclonal Sheep IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all IFN-alpha/beta R2 Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human IFN-alpha / beta R2
Ile27-Lys243
Accession # P48551

Specificity

Detects human IFN-alpha / beta R2 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross‑reactivity with recombinant mouse IFN-alpha / beta R2, recombinant human (rh) IFN-gamma  R1, and rhIFN-gamma  R2 is observed.

Clonality

Polyclonal

Host

Sheep

Isotype

IgG

Applications for IFN-alpha/beta R2 Antibody [PE]

Application
Recommended Usage

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: IFN-alpha/beta R2

IFNAR2, also known as Interferon alpha/beta receptor 2, has 3 isoforms, an isoform 1 that is 515 amino acid and 58 kDa, an isoform 2 that is 331 amino acid and 37 kDa, and an isoform3 that is 239 amino acid and 27 kDa; expressed in blood cells, lymphoblastoid and fibrosarcoma cell lines, isoform 3 is detected in the urine; is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta, stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Current research is being performed on several diseases and disorders including interferon, hepatitis c, hepatitis b, multiple sclerosis, measles, hepatocellular carcinoma, liver disease, breast cancer, myeloma, carcinoma, melanoma, adenocarcinoma, respiratory syncytial virus bronchiolitis, portal vein thrombosis, dengue hemorrhagic fever, cervical intraepithelial neoplasia, renal cell carcinoma, hemorrhagic fever, hepatitis c, and japanese encephalitis. This protein has been shown to interact with over 50 proteins including USP18, STAT2, GNB2L1, JAK1, and IFNA13 in cytokine-cytokine receptor interaction, osteoclast differentiation, toll-like receptor signaling pathway, Jak-STAT signaling pathway, natural killer cell mediated cytotoxicity, hepatitis C, measles, THC differentiation pathway, regulation of IFNA signaling and influenza A pathways.

Long Name

Interferon alpha/beta Receptor 2

Alternate Names

IFN-aR2, IFN-bR2, IFNAR2, IFNbR2

Gene Symbol

IFNAR2

Additional IFN-alpha/beta R2 Products

Product Documents for IFN-alpha/beta R2 Antibody [PE]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for IFN-alpha/beta R2 Antibody [PE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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