Human p18INK4c/CDKN2C Alexa Fluor® 594-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF7746T
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Alexa Fluor 594 (Excitation = 590 nm, Emission = 617 nm)
Antibody Source
Polyclonal Goat IgG
Product Specifications
Immunogen
E. coli-derived recombinant human p18INK4c/CDKN2C
Ala2-Gln168
Accession # P42773
Ala2-Gln168
Accession # P42773
Specificity
Detects human p18INK4c/CDKN2C in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross-reactivity with recombinant human p19INK4d is observed.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications for Human p18INK4c/CDKN2C Alexa Fluor® 594-conjugated Antibody
Application
Recommended Usage
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Antigen Affinity-purified
Formulation
Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
Background: p18INK4c/CDKN2C
p18INK4c (18 kDa Inhibitor of CDK4-c; also p18-INK6 and cyclin-dependent kinase 6 inhibitor) is an 18-19 kDa member of the CDKN2 cyclin-dependent kinase inhibitor family of molecules. It is expressed in skeletal muscle, macrophages, T cells and B cells where it serves as a negative regulator of cell proliferation. It does so by specifically associating with either CDK4 or, principally, CDK6, thereby blocking cyclin binding and the activity that leads to a G1-to-S cell cycle transition. In the case of B cells, this activity is necessary for the development of plasma cells. Human p18INK4c is 168 amino acids (aa) in length. It contains four "L" shaped ankyrin repeats (aa 4-132) that interact with cyclin. The C-terminus is described as containing a fifth ankyrin repeat, one that may act to reverse cell cycle repression. Full-length human p18INK4c shares 92% aa sequence identity with mouse p18INK4c.
Long Name
p18 Cyclin Dependent Kinase 4 Inhibitor 2C
Alternate Names
CDKN2C, p18-INK6
Gene Symbol
CDKN2C
UniProt
Additional p18INK4c/CDKN2C Products
Product Specific Notices for Human p18INK4c/CDKN2C Alexa Fluor® 594-conjugated Antibody
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
For research use only
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