Species Reactivity:

Human

Immunogen:

KLH-coupled human NAIP synthetic peptide
YLSLSSTRPDEGLASIIC
Accession # NP_004527

Applications:

Western Blot

Label:

Alexa Fluor 405 (Excitation=405 nm, Emission=421 nm)

Specificity:

Detects human NAIP expressed in Sf 21 insect cells.

View Full Technical Details for Human NAIP Alexa Fluor® 405-conjugated Antibody

Technical Data
Citations / Reviews

Applications for Human NAIP Alexa Fluor® 405-conjugated Antibody

	Recommended Concentration	Sample
Western Blot	Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application.

Formulation, Preparation and Storage

Purification	Antigen Affinity-purified
Formulation	Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Shipping	The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage	Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

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Background: NAIP

Neuronal apoptosis inhibitory protein (NAIP; also Baculoviral IAP repeat-containing protein 1) is a 160 kDa member of the inhibitor of apoptosis family of proteins (also known as BIRC proteins). Human NAIP is 1403 amino acids (aa) in length. It contains three distinct regions: an N-terminal cluster of three baculoviral inhibitory repeat (BIR) domains, a central nucleotide binding oligomerization domain (NOD), and a C-terminal leucine-rich repeat (LRR) domain. Human NAIP shares 68% aa identity with mouse NAIP. NAIP is expressed in motor neurons, but not in sensory neurons. It is also expressed in the liver, placenta and to a lesser extent in the spinal cord. NAIP prevents motor neuron apoptosis, and defects in NAIP have been found in individuals with spinal muscular atrophy.

Item	Value
Long Name	Neuronal Apoptosis Inhibitor Protein
Entrez Gene IDs	4671 (Human); 17940 (Mouse); 191568 (Rat)
Alternate Names	BIRC1, BIRC1baculoviral IAP repeat-containing protein 1, FLJ18088, FLJ42520, FLJ58811, NAIP, NLR family, BIR domain containing 1, NLR family, apoptosis inhibitory protein, NLRB1, Neuronal apoptosis inhibitory protein, baculoviral IAP repeat-containing 1, nucleotide-binding oligomerization domain, leucine rich repeat and BIR domaincontaining 1, psi neuronal apoptosis inhibitory protein, psiNAIP

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Product Documents for Human NAIP Alexa Fluor® 405-conjugated Antibody

Product Datasheets

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Human NAIP Alexa Fluor® 405-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # AF829V

Key Product Details