MSP, also known as hepatocyte growth factor-like protein (HGFl), and scatter factor-2 (SF2), is a member of the HGF family of growth factors. It is secreted as a single chain inactive precursor which is proteolytically activated to yield a biologically active disulfide-linked heterodimer of the alpha and beta chains. MSP induces keratinocyte proliferation, bone resorption, and cell migration and shape change in resident macrophages. Heterodimeric MSP binds to and activates the cell surface receptor tyrosine kinase, RON/STK, which is expressed on mature macrophages, keratinocytes, and vascular endothelium of wounded skin.

Long Name

Macrophage Stimulating Protein/Macrophage Stimulating 1 [Hepatocyte Growth Factor-like]

Entrez Gene IDs

4485 (Human); 15235 (Mouse); 24566 (Rat)

Gene Symbol

MST1

UniProt

P26927

Additional MSP/MST1 beta Chain Products

Product Documents for Human MSP/MST1 beta Chain Alexa Fluor Plus 488 MAb (Clone 68

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SDS

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Product Specific Notices for Human MSP/MST1 beta Chain Alexa Fluor Plus 488 MAb (Clone 68

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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Human MSP/MST1 beta Chain Alexa Fluor Plus 488 MAb (Clone 68

R&D Systems, part of Bio-Techne | Catalog # FAB735AFP488

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

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Product Specifications

Specificity

Clonality

Host

Isotype

Applications for Human MSP/MST1 beta Chain Alexa Fluor Plus 488 MAb (Clone 68

Blockade of Receptor-ligand Interaction

Western Blot

Background: MSP/MST1 beta Chain