Bcl-w is a member of the Bcl-2 family of proteins that regulates outer mitochondrial membrane permeability (1, 2). Bcl-w is an anti-apoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Bcl-w is required for normal sperm maturation (3, 4, 5). Natural Bcl-w contains a carboxyl-terminal mitochondria targeting sequence. Recombinant Bcl-w missing the mitochondrial targeting sequence maintains its ability to neutralize pro-apoptotic Bcl-2 family members. Neutralization by Bcl-w appears to be through binding the BH3 region of pro-apoptotic Bcl-2 family members. This activity does not require the mitochondrial targeting sequence.

References

Gross, A. et al. (1999) Genes and Develop. 13:1899.
Kroemer, G. (1997) Nature Med. 3:614.
Ross, J.A., et al. (1998) Nat. Genet. 18:251.
Print, C.G. et al. (1998) Proc. Natl. Acad. Sci. USA 95:12323.
Yan, W. et al. (2000) Mol. Endocrin. 14:682.

Long Name

B Cell Lymphoma/Leukemia w

Alternate Names

BCL2L2, Bclw

Entrez Gene IDs

599 (Human); 12050 (Mouse)

Gene Symbol

BCL2L2

UniProt

Q92843

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Product Specific Notices

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

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Human/Mouse Bcl-w Alexa Fluor™ Plus 680-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB8241AFP680

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

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Product Specifications

Specificity

Clonality

Host

Isotype

Applications

Neutralization

Background: Bcl-w