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Human METTL3 Alexa Fluor® 700-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB11514N

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunocytochemistry

Label

Alexa Fluor 700 (Excitation = 675-700 nm, Emission = 723 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 1075034

Product Specifications

Immunogen

METTL3 containing Synthetic Peptide
Accession # Q86U44

Specificity

Detects human METTL3.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human METTL3 Alexa Fluor® 700-conjugated Antibody

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: METTL3

METTL3 is a 70 kDa subunit and is the sole catalytic subunit in the methyltransferase complex which catalyzes N6-methyladenosine. N6-methlyladenosine is the most abundant mRNA modification. The full-length METTL3 protein consists of 580 amino acids. METTL3 plays a key role in a variety of cancers and expression is dysregulated via different mechanisms. It plays a critical role in tumorigenesis, tumor growth, metastasis, metabolic reprogramming, immune cell infiltration, and tumor drug resistance. METTL3 can be an oncogene through depositing m6A modifications on critical transcripts. In some cases, it can also be a tumor suppressor possibly by promoting cell cycle arrest in the G1 phase.

Long Name

Methyltransferase like 3

Alternate Names

adoMet-binding subunit of the human mRNA (N6-adeno, hMETTL3, IME4, mRNA m(6)A methyltransferase, MT-A70, N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase catalytic subunit, Spo8

Entrez Gene IDs

56339 (Human); 56335 (Mouse); 361035 (Rat)

Gene Symbol

Q86U44

UniProt

Additional METTL3 Products

Product Documents

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human METTL3 Alexa Fluor® 700-conjugated Antibody


This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

For research use only

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