Human IFN-gamma R1/CD119 PE-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # FAB673P
Conjugate
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Cited:
Human
Applications
Validated:
Flow Cytometry
Cited:
Flow Cytometry
Label
Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)
Antibody Source
Monoclonal Mouse IgG1 Clone # 92101
Product Specifications
Immunogen
Mouse myeloma cell line NS0-derived recombinant human IFN-gamma R1
Glu18-Gly245
Accession # P15260.1
Glu18-Gly245
Accession # P15260.1
Specificity
Detects human IFN-gamma R1 in direct ELISAs and Western blots. In direct ELISAs, this antibody does not cross-react with recombinant mouse IFN‑ gamma R1, recombinant human (rh) IFN-gamma R2, or rhIL-10 R beta.
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Scientific Data Images for Human IFN-gamma R1/CD119 PE-conjugated Antibody
Detection of IFN-gamma R1/CD119 in Human Blood Monocytes by Flow Cytometry.
Human peripheral blood monocytes were stained with Mouse Anti-Human IFN-gamma R1/CD119 PE-conjugated Monoclonal Antibody (Catalog # FAB673P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.Applications for Human IFN-gamma R1/CD119 PE-conjugated Antibody
Application
Recommended Usage
Flow Cytometry
10 µL/106 cells
Sample: Human peripheral blood monocytes
Sample: Human peripheral blood monocytes
Reviewed Applications
Read 1 review rated 4 using FAB673P in the following applications:
Spectra Viewer
Plan Your Experiments
Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.
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Formulation, Preparation, and Storage
Purification
Protein A or G purified from ascites
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.
Background: IFN-gamma R1/CD119
The high-affinity IFN-gamma receptor complex is made up of two type I transmembrane proteins, IFN-gamma R1 (IFN-gamma R alpha) and IFN-gamma R2 (IFN-gamma R beta). Both proteins are members of the type II cytokine receptor family and share approximately 52% amino acid sequence identity. IFN-gamma R1 is the ligand-binding subunit that is necessary and sufficient for IFN-gamma binding and receptor internalization. IFN-gamma R2 is required for IFN-gamma signaling but does not bind IFN-gamma by itself. Human IFN-gamma R1 cDNA encodes a 489 amino acid (aa) residue protein with a 17 aa signal peptide, a 228 aa extracellular domain, a 23 aa transmembrane domain, and a 221 aa intracellular domain. Human and mouse IFN-gamma R1 share 52% amino acid sequence identity and bind IFN-gamma in a species-specific manner. IFN-gamma R1 is constitutively expressed in most cell types. Soluble IFN-gamma R1 that binds IFN-gamma has been detected in biological fluids.
Long Name
Interferon gamma Receptor 1
Alternate Names
CD119, IFN-gR1, IFNgammaR1, IFNGR1
Gene Symbol
IFNGR1
UniProt
Additional IFN-gamma R1/CD119 Products
Product Documents for Human IFN-gamma R1/CD119 PE-conjugated Antibody
Product Specific Notices for Human IFN-gamma R1/CD119 PE-conjugated Antibody
For research use only
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