Human Fer Alexa Fluor™ Plus 488-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB7229AFP488

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FAB7229AFP488-100UG
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Monoclonal Mouse IgG1 Clone # 690318

View all Fer Antibodies »

Product Specifications

Specificity

Detects human Fer in direct ELISAs.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human Fer Alexa Fluor™ Plus 488-conjugated Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Background: Fer

FER [feline encephalitis virus (FES)-related kinase], also called Tyk3, is a widely expressed 822 amino acid (aa), 94 kDa intracellular non-receptor tyrosine kinase of the FES/FPS family. Human FER contains an FCH (microtubule/cytoskeleton interaction) domain (aa 1‑58), a coiled coil oligomerization region, an SH2 domain (aa 460‑550) and a kinase domain (aa 563‑816). FER is found both in the cytoplasm and the nucleus, and interacts with several transmembrane receptors, cytosolic proteins, and nuclear chromatin. Through its interactions and kinase activity, Tyk3/FER influences synapse formation, cytoskeletal rearrangement, cell survival and cell cycle progression. Within the region used as an immunogen, human Tyk3/FER shares 97% aa sequence identity with mouse Tyk3/FER. Potential human Tyk3/FER isoforms truncated at aa 308 and 478 have been described.

Long Name

Feline Encephalitis Virus-related Kinase

Alternate Names

Phosphoprotein NCP94, TYK3

Entrez Gene IDs

2241 (Human); 14158 (Mouse); 301737 (Rat)

Gene Symbol

FER

UniProt

P16591 (Human)

Additional Fer Products

Product Documents

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human Fer Alexa Fluor™ Plus 488-conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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