Human DOCK2 Alexa Fluor™ Plus 594-conjugated Antibody
R&D Systems, part of Bio-Techne | Catalog # AF5339AFP594
Conjugate
Catalog #
Key Product Details
Species Reactivity
Human
Applications
Western Blot
Label
Alexa Fluor Plus 594 (Excitation = 590 nm, Emission = 618 nm)
Antibody Source
Polyclonal Goat IgG
Product Specifications
Immunogen
E. coli-derived recombinant human DOCK2
Specificity
Detects human DOCK2 in Western blots.
Clonality
Polyclonal
Host
Goat
Isotype
IgG
Applications for Human DOCK2 Alexa Fluor™ Plus 594-conjugated Antibody
Application
Recommended Usage
Western Blot
Optimal dilution of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Formulation
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
Background: DOCK2
DOCK2 (Dedicator of cytokinesis protein 2) is a member of the DOCK-A family, DOCK180 superfamily of proteins. Its predicted molecular weight is 210 kDa, although it may run approximately at 190 kDa in SDS-PAGE. It is found in hematopoietic cell types, and regulates the activity of the GTPases Rac-1 and -2. Human DOCK2 is 1830 amino acids (aa) in length. It contains one SH3 domain (aa 8‑69), a DHR-1 region that localizes DOCK2 to the plasma membrane (aa 420‑662), and a DHR-2 domain that binds to nucleotide-free GTPases and shows GEF activity (aa 1115‑1621). There are two isoform variants, one that shows a 38 aa substitution for Tyr1405, and a second that shows a start site at Met450 with accompanying deletions of aa 462‑494 and 630‑766, and a 22 aa substitution for aa 934‑1830. Over aa 420‑642, human DOCK2 shares 96% aa identity to mouse DOCK2.
Long Name
Dedicator of Cytokinesis Protein 2
Alternate Names
dedicator of cytokinesis 2, dedicator of cytokinesis protein 2, FLJ46592, KIAA0209dedicator of cyto-kinesis 2
Gene Symbol
DOCK2
UniProt
Additional DOCK2 Products
Product Specific Notices for Human DOCK2 Alexa Fluor™ Plus 594-conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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