Human Claudin-4 PE-conjugated Antibody

R&D Systems, part of Bio-Techne | Catalog # FAB4219P

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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Phycoerythrin (Excitation = 488 nm, Emission = 565-605 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # 382321

View all Claudin-4 Antibodies »

Product Specifications

Immunogen

NS0 mouse myeloma cell line transfected with human Claudin-4
Met1-Val209
Accession # NP_001296

Specificity

Detects human Claudin‑4. Stains human Claudin-4 transfectants but not irrelevant transfectants. Recognizes an epitope in the first extracellular loop (aa Met29-Arg81).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Scientific Data Images for Human Claudin-4 PE-conjugated Antibody

Detection of Claudin-4 antibody in PC-3 Human Cell Line antibody by Flow Cytometry.

Detection of Claudin‑4 in PC‑3 Human Cell Line by Flow Cytometry.

PC-3 human prostate cancer cell line was stained with Mouse Anti-Human Claudin-4 PE-conjugated Monoclonal Antibody (Catalog # FAB4219P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Applications for Human Claudin-4 PE-conjugated Antibody

Application
Recommended Usage

Flow Cytometry

10 µL/106 cells
Sample: PC‑3 human prostate cancer cell line

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: Claudin-4

Claudin-4 is a multipass membrane protein in the claudin family of tight junction proteins. Claudin-4 is a 209 amino acid molecule with four transmembrane segments. It is preferentially expressed in intestinal mucosa epithelium and is involved in epithelial tissue development. It is also up‑regulated in several carcinomas. Phosphorylation of Claudin-4 regulates paracellular epithelial permeability. Human Claudin-4 shares 83% aa sequence identity with mouse and rat Claudin-4.

Alternate Names

Claudin4, CLDN4, CPE-R, CPETR1, WBSCR8

Entrez Gene IDs

1364 (Human); 12740 (Mouse); 304407 (Rat)

Gene Symbol

CLDN4

UniProt

NP_001296

Additional Claudin-4 Products

Product Documents for Human Claudin-4 PE-conjugated Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Claudin-4 PE-conjugated Antibody

For research use only

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