Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Western Blot

Cited:

ELISA Detection

Label

Biotin

Antibody Source

Polyclonal Goat IgG

View all Arylsulfatase A/ARSA Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human ARSA
Arg19-Ala507
Accession # AAH14210

Specificity

Detects human Arylsulfatase A/ARSA in Western blots. In Western blots, approximately 50% cross-reactivity with recombinant mouse ARSA is observed.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human Arylsulfatase A/ARSA Biotinylated Antibody

Application
Recommended Usage

Western Blot

0.1 µg/mL
Sample: Recombinant Human Arylsulfatase A/ARSA (Catalog # 2485-SU)

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Reconstitution Buffer Available:
Size / Price
Qty

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Arylsulfatase A/ARSA

As a member of the sulfatase family, ARSA is required for the lysosomal degradation of cerebroside-3-sulfate, a sphingolipid sulfate ester and a major constituent of the myelin sheet (1). The ARSA deficiency results in metachromatic leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms (2). The deduced amino acid sequence of human ARSA consists of a signal peptide (residues 1-18) and a mature chain (residues 19-507) (3). Recombinant human ARSA corresponds to the mature chain and has sulfatase activity described above.

References

  1. Lukatela, G. et al. (1998) Biochemistry 37:3654.
  2. Parenti, G. et al. (1997) Curr. Opin. Genet. & Dev. 7:386.
  3. Stein, C. et al. (1989) J. Biol. Chem. 264:1252.

Alternate Names

ARSA, Cerebroside 3-sulfatase

Entrez Gene IDs

410 (Human); 11883 (Mouse)

Gene Symbol

ARSA

UniProt

AAH14210

Additional Arylsulfatase A/ARSA Products

Product Documents for Human Arylsulfatase A/ARSA Biotinylated Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Arylsulfatase A/ARSA Biotinylated Antibody

For research use only

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