ErbB2/Her2 [p Tyr1248] Antibody (24GB4415)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-50795

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # 24GB4415

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all ErbB2/Her2 Antibodies »

Product Specifications

Immunogen

A synthesized peptide derived from human Phospho-ErbB2/Her2 (Tyr1248/Tyr1173) (Uniprot: P04626)

Modification

p Tyr1248

Specificity

This antibody detects endogenous levels of ERBB2 only when phosphorylated at Y1248 or Y1173

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Applications for ErbB2/Her2 [p Tyr1248] Antibody (24GB4415)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: ErbB2/Her2

ErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.

Long Name

Receptor Tyrosine Protein Kinase ErbB2

Alternate Names

CD340, HER2, Neu Oncogene, NGL, TKR1

Gene Symbol

ERBB2

Additional ErbB2/Her2 Products

Product Documents for ErbB2/Her2 [p Tyr1248] Antibody (24GB4415)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ErbB2/Her2 [p Tyr1248] Antibody (24GB4415)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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