Epsin-2 Antibody (24GB8190)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-51852

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NBP3-51852-100ul
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Key Product Details

Species Reactivity

Human

Applications

Western Blot, Flow Cytometry, Knockdown Validated

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 24GB8190

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Epsin-2 Antibodies »

Product Specifications

Immunogen

Recombinant protein of human Epsin-2 (Uniprot: O95208)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Epsin-2 Antibody (24GB8190)

Epsin-2 Antibody (24GB8190)

Flow Cytometry: Epsin-2 Antibody (24GB8190)[NBP3-51852] -

Flow cytometric analysis of Epsin-2expression in HeLa cells using Epsin-2 antibody (1:1,000). Green, isotype control; red, Epsin 2.
Epsin-2 Antibody (24GB8190)

Western Blot: Epsin-2 Antibody (24GB8190)[NBP3-51852] -

Western blotting analysis using Epsin-2 antibody (1:2,500) and HRP-conjugated goat anti-mouse secondary antibody (1:20,000) respectively. Image was developed using NaQ(TM) ECL Substrate Kit.

Applications for Epsin-2 Antibody (24GB8190)

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Epsin-2

Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation. Miscues in RTK signaling pathways can result in cellular transformation and ultimately in cancer. Two novel EGF receptor substrates designated EGF-receptor pathway substrates 8 and 15, or Eps8 and Eps15, have been described. Epsin is a 90 kDa binding partner to Eps15. Both epsin and Eps15 have an ubiquitous tissue distribution but are concentrated in presynaptic nerve terminals specialized for the Clathrin-mediated endocytosis of synaptic vesicles. Disruption of epsin function blocks Clathrinmediated endocytosis. Epsin along with its binding partner Eps15 is proposed to be involved in the assistance of Clathrin coat rearrangement during Clathrin coated pit invagination. Epsin 2 and epsin 2a are also associated with Clathrin-mediated endocytosis and are enriched in the brain in the peri-Golgi region.

Alternate Names

Eps15 binding protein, EPS-15-interacting protein 2, epsin 2, epsin-2, KIAA1065EHB21

Gene Symbol

EPN2

Additional Epsin-2 Products

Product Documents for Epsin-2 Antibody (24GB8190)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Epsin-2 Antibody (24GB8190)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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