Dopa Decarboxylase/DDC Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-1785

Discontinued Product
NB100-1785 has been discontinued. View all Dopa Decarboxylase/DDC products.

Key Product Details

Species Reactivity

Human

Applications

Western Blot, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Dopa Decarboxylase/DDC Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-WEHIKELAADVL corresponding to C-Terminus according to NP_000781.1, NP_001229815.1, NP_001229816.1, NP_001229817.1, NP_001229818.1.

Specificity

This antibody is expected to recognise isoforms 1, 2, 3, 4 and 5 (NP_000781.1; NP_001229815.1; NP_001229816.1; NP_001229817.1; NP_001229818.1 respectively). Reported variants represent identical protein (NP_000781.1; NP_001076440.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Dopa Decarboxylase/DDC Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:8000

Western Blot

0.03 - 0.1 ug/ml
Application Notes
WB: Approx. 50 kDa band observed in human kidney lysates and 48 kDa band on human brain lysates (calculated MW of 53.9 kDa band according to NP_000781.1).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris (pH 7.3), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Dopa Decarboxylase/DDC

DOPA decarboxylase is an enzyme implicated in 2 metabolic pathways, synthesizing 2 important neurotransmitters: dopamine and serotonin which both play key roles in many clinical disorders, including Parkinson's disease. Following the hydroxylation of tyrosine to form L dihydroxyphenylalanine (LDOPA), catalyzed by tyrosine hydroxylase, DDC decarboxylates LDOPA to form dopamine. This neurotransmitter is found in different areas of the brain and is particularly abundant in basal ganglia. Dopamine is also produced by DDC in the sympathetic nervous system and is the precursor of the catecholaminergic hormones, noradrenaline and adrenaline in the adrenal medulla. In the nervous system, tryptophan hydroxylase produces 5 OH tryptophan, which is decarboxylated by DDC, giving rise to serotonin. DDC is a homodimeric, pyridoxal phosphate dependent enzyme.

Alternate Names

AADC, DDC

Entrez Gene IDs

1644 (Human)

Gene Symbol

DDC

UniProt

NP_000781.1 (Human)

Additional Dopa Decarboxylase/DDC Products

Product Documents for Dopa Decarboxylase/DDC Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Dopa Decarboxylase/DDC Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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