CD27 Ligand/TNFSF7/CD70 Antibody [ADC] - (Vorsetuzumab Mafodotin, Research Grade)

ADC

Monoclonal Human IgG₁

LYOPH mg/ml

CD27 Ligand/TNFSF7 (Uniprot: P32970)

Monoclonal

Human

IgG₁

146.1 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

This product is an Antibody-Drug Conjugate (ADC) for Research Use Only (RUO).

Vorsetuzumab mafodotin is a humanized anti-CD70 monoclonal antibody attached to a potent, synthetic drug payload, monomethyl auristatin F (MMAF) utilizing Seattle Genetics' proprietary antibody-drug conjugate (ADC) technology. CD70 is expressed on a variety of solid tumors, including renal cell carcinoma, pancreatic, ovarian and lung cancer, as well as multiple myeloma and several types of non-Hodgkin lymphoma.

This product is shipped at ambient temperature. Upon receipt, store immediately at -20C or lower for 12 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

> 90% by SDS-PAGE and HPLC

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

No Preservative

LYOPH mg/ml

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Store at -20C in powder form. Store at -80C once reconstituted.