APCDD1 Antibody (DMC479) - Chimeric

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-48363

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-48363-100ug
NBP3-48363-10ug
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # DMC479

Concentration

LYOPH mg/ml

View all APCDD1 Antibodies »

Product Specifications

Immunogen

APCDD1 recombinant protein expressed in mammalian cells (Accession# Q8J025). The exact amino acid sequence is proprietary.

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Description

This product is shipped at ambient temperature. Store at -20C to -80C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80C (Avoid repeated freezing and thawing).

Applications for APCDD1 Antibody (DMC479) - Chimeric

Application
Recommended Usage

Flow Cytometry

1:100

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified from cell culture supernatant

Reconstitution

.

Formulation

PBS, pH 7.4, 5-8% Trehalose

Preservative

Trehalose

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C in powder form. Store at -80C once reconstituted.

Background: APCDD1

Adenomatosis polyposis coli down-regulated 1 protein (APCDD1), also known as DRAPC1, is a negative regulator of the Wnt signaling pathway. APCDD1 acts to inhibit Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin interaction. APCDD-1 is most strongly expressed in pancreas, heart, prostate, ovary, lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. APCDD1 is expressed in both the epidermal and dermal compartments of the hair follicle, and in the dermal papilla, the matrix, and the hair shaft. Mutations in the APCDD1 gene cause hypotrichosis simplex (HTS), a rare form of non-syndromic hereditary hypotrichosis characterized by progressive hairloss in early childhood. The APCDD1 protein has also been found overexpressed in colorectal carcinogenesis and is deregulated in CTNNB1-mutated Wilms tumors.

APCDD1 antibodies may be useful for hair loss studies and research on certian cancers.

Long Name

APC Down Regulated 1

Alternate Names

APC Down Regulated 1, DRAPC1, HYPT1

Gene Symbol

APCDD1

Additional APCDD1 Products

Product Documents for APCDD1 Antibody (DMC479) - Chimeric

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for APCDD1 Antibody (DMC479) - Chimeric

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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