ACE-2 Antibody (MSVA-919R)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-52491

Recombinant Monoclonal Antibody
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NBP3-52491-0.1ml
NBP3-52491-0.5ml
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # MSVA-919R

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all ACE-2 Antibodies »

Product Specifications

Immunogen

Recombinant fragment (around aa705-805) of human ACE2 (exact sequence is proprietary)

Localization

Cytoplasmic

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Description

This antibody is highly specific and optimized for use in Immunohistochemistry.

It has been validated on TMAs covering 76 normal tissues and numerous cancer tissues.

The antibody concentration is optimized for dilution within dilution range using commercially available antibody diluent for immunohistochemistry.

Positive Control
Kidney: Cells of proximal tubuli should show a moderate to strong ACE2 immunostaining with accentuation of the staining at the apical membrane.

Negative Control
Kidney: Cells of distal tubuli and glomeruli should not show ACE2 immunostaining.

Storage
Antibody can be stored at 4°C. For extended storage, aliquot and store at -20°C. Avoid repeated freeze-thaw cycles.

Scientific Data Images for ACE-2 Antibody (MSVA-919R)

ACE-2 Antibody (MSVA-919R) Immunohistochemistry: ACE-2 Antibody (MSVA-919R) [NBP3-52491]

Immunohistochemistry: ACE-2 Antibody (MSVA-919R) [NBP3-52491]

Leydig cells and spermatocytes of the testis show a particularly strong ACE2 immunostaining in the testis.
ACE-2 Antibody (MSVA-919R) Immunohistochemistry: ACE-2 Antibody (MSVA-919R) [NBP3-52491]

Immunohistochemistry: ACE-2 Antibody (MSVA-919R) [NBP3-52491]

A strong ACE2 immunostaining occurs in proximal tubuli of the kidney.
ACE-2 Antibody (MSVA-919R) Immunohistochemistry: ACE-2 Antibody (MSVA-919R) [NBP3-52491]

Immunohistochemistry: ACE-2 Antibody (MSVA-919R) [NBP3-52491]

Clear cell renal cell carcinoma strong membranous ACE2 positivity.
View 8 more images

Applications for ACE-2 Antibody (MSVA-919R)

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:100 1:200

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10mM PBS with <1% BSA

Preservative

<0.1% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4°C.

Background: ACE-2

Angiotensin I Converting Enzyme 2 (ACE2), also known as ACEH (ACE homologue), is an integral membrane protein and a zinc metalloprotease of the ACE family (theoretical molecular weight 92 kDa). The predicted mouse ACE2 protein sequence consists of 798 amino acids, including an N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. Mouse ACE2 is 40% homologous in amino acid identity to the N- and C-terminal domains of mouse somatic ACE. Enzymatically, ACE2 converts the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts Ang I to Ang II.

Genetic data from Drosophila, mice and rats show that the ACE2 protein is an essential regulator of heart function in vivo. ACE2 mRNA is found at high levels in testis, kidney and heart with moderate levels in colon, small intestine, and ovary. The ACE2 protein contributes to organ function through the renin-angiotensin system, playing a central role in vascular, renal, and myocardial physiology.

Virology research has demonstrated that the severe acute respiratory syndrome coronavirus (SARS-CoV) spike protein binds to its functional receptor, ACE2 (1). Vimentin is a type III intermediate filament protein expressed in mesenchymal cells that helps comprise the cytoskeleton in all animal cells. Studies have demonstrated that vimentin allows cell binding that allows the uptake of SARS-CoV spike protein into a host (2). This direct interaction of SARS-CoV with vimentin has been identified as an entry mechanism for the virus into a host, mediated by the SARS-CoV receptor ACE2 (1,2). It has been shown that ACE2 is the SARS-CoV-2 receptor required for cell entry and plays a physiological role in the replication of SARS-CoV in an infected host (1). Studies using human ACE2 antibody demonstrated a blockade of SARS-CoV-2 and ACE2 interaction, indicating an important physiological component of viral transmission and potential anti-viral therapeutic strategies (3).

References

1. Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., . . . Farzan, M. (2003). Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature, 426(6965), 450-454. doi:10.1038/nature02145

2. Yu YT, Chien SC, Chen IY, Lai CT, Tsay YG, Chang SC, Chang MF. (2016) Surface vimentin is critical for the cell entry of SARS-CoV. J Biomed Sci. doi: 10.1186/s12929-016-0234-7

3. Hoffmann, M., Kleine-Weber, H., Schroeder, S., Kruger, N., Herrler, T., Erichsen, S., . . . Pohlmann, S. (2020). SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. doi:10.1016/j.cell.2020.02.052

Long Name

Angiotensin I Converting Enzyme 2

Alternate Names

ACE2, ACEH

Gene Symbol

Q9BYF1, ACE2

Additional ACE-2 Products

Product Documents for ACE-2 Antibody (MSVA-919R)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for ACE-2 Antibody (MSVA-919R)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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