Enabling Visualization of Functional Protein Interactions
Built upon Advanced Cell Diagnostics RNAscope™ technology, this novel ProximityScope™ assay is designed to reveal functional protein-protein interactions within intact tissues, delivering a spatial solution to explore how molecular signaling shapes disease processes. This assay will enable researchers to enable studying effectiveness of biologics for patient stratification or therapeutic optimization— offering a truly integrated spatial multiomic view.
Advancing Research, Therapeutic and Diagnostic Development with ProximityScope
Biological Insights in Health and Disease
Biological Insights in Health and Disease
Certain protein interactions promote signaling pathways that promote disease progression.
Patient Stratification
Patient Stratification
Protein interactions such as receptor dimerization can promote tumor growth making such tumors ‘pathway dependent’ to that signaling pathway.
Inhibitors against that pathway can be the right course of treatment for patient with such tumors.
Therapeutic Optimization
Therapeutic Optimization
Therapeutics that are designed to bind 2 different targets need to be optimized to ensure high specificity and low toxicity.
ProximityScope Enabled for RNAscope™ Multiomic LS Assay
The protein proximity assay provides a clear visual signal at subcellular resolution, built to be compatible with the RNAscope™ Multiomic LS workflow on Bond Rx, allowing same-section visualization of protein-protein interactions, RNA and proteins
RNAscope™ Multiomic LS Assay
ProximityScope Image Gallery
Cell-Cell Interactions
Cell-Cell Interactions
Interactions between surface proteins from different cells.
Cell Surface Interactions
Cell Surface Interactions
Interactions/proximity between surface proteins on same cell.
Intracellular Interactions
Intracellular Interactions
Interactions between proteins within cellular complexes or signaling cascades.
AACR 2025 ProximityScope™ Poster
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