Wnt-1 Small Molecules and Peptides

Wnt-1 is a secreted glycoprotein that binds members of the Frizzled family of seven transmembrane domain receptors. First identified as a proto-oncogene activated in mouse model of mammary tumors, Wnt-1 is known to exert a wide range of functions. Effects of Wnt-1 include control of cell proliferation, patterning, motility, and fate determination. The secretion of Wnt-1 plays an important role in embryonic development and carcinogenesis. Wnt-1 may also affect morphogenesis of the neural tube ...