64 results for "Raf-1" in Products
Raf-1 Products
Raf-1 is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. The activated Raf-1 can phosphorylate and activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the Serine/Threonine specific protein kinases ERK1 and ERK2. Downstream of Raf-1, activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation, and cell migration.
Potent, selective c-Raf1 kinase inhibitor
| Chemical Name: | 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one |
| Purity: | ≥95% (HPLC) |
Potent Raf-1 inhibitor; also inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and cKIT
| Chemical Name: | 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide |
| Purity: | ≥98% (HPLC) |
Potent BRAF and CRAF inhibitor
| Chemical Name: | N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Rat |
| Details: | Mouse IgG2b Kappa Monoclonal Clone #1H4 |
| Applications: | WB, ELISA, Func, Mycoplasma |
![Western Blot: Raf-1 Antibody (1H4) [H00005894-M03]](https://resources.bio-techne.com/images/products/Raf-1-Antibody-1H4-Western-Blot-H00005894-M03-img0007.jpg "Western Blot: Raf-1 Antibody (1H4) [H00005894-M03]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
| Chemical Name: | 2-(Methylthio)-6-[4-[5-[[3-(trifluoromethyl)phenyl]amino]-1H-1,2,4-triazol-3-yl]phenoxy]-4-pyrimidinamine |
| Purity: | ≥98% (HPLC) |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SR2181 |
| Applications: | IHC, WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Applications: | WB, Simple Western, IHC |
Potent Raf kinase inhibitor
| Chemical Name: | 3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #23GB2640 |
| Applications: | WB, ICC/IF, Flow, Mycoplasma |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG2a Monoclonal Clone #563002 |
| Applications: | WB, IHC |
| Reactivity: | Human |
| Details: | Mouse IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: Raf-1 Antibody [H00005894-B01P]](https://resources.bio-techne.com/images/products/Raf-1-Antibody-Western-Blot-H00005894-B01P-img0004.jpg "Western Blot: Raf-1 Antibody [H00005894-B01P]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, ICC/IF |
![Immunocytochemistry/ Immunofluorescence: Raf-1 Antibody [NBP1-85462]](https://resources.bio-techne.com/images/products/Raf-1-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-85462-img0006.jpg "Immunocytochemistry/ Immunofluorescence: Raf-1 Antibody [NBP1-85462]")