Osteopontin/OPN Antibodies

Osteopontin (OPN), also known as bone sialoprotein (BSP), is a secreted SIBLING family protein that can be variably modified by O- and N-glycosylation, sulfation, phosphorylation, and transglutamination. OPN is widely expressed and is prominent in mineralized tissues. It inhibits bone mineralization and kidney stone formation and promotes inflammation, cell ad­hesion, and migration. Its expression is upregulat­ed during inflammation, obesity, atherosclerosis, cancer, and tissue damage and ...