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287 results for "Nicastrin" in Products

Nicastrin Products

Nicastrin (NCT) is a 150 - 160 kDa member of the nicastrin family of proteins. It is a component of the aspartyl protease γ-secretase complex and serves to stabilize and direct γ-secretase components to proper positions in the plasma membrane. The γ-secretase complex mediates the cleavage of intramembrane proteins such as notch-1 and APP. Mature human nicastrin is a 676 amino acid type I transmembrane glycoprotein. It contains a 636 aa extracellular domain (aa 34 - 669) that shows a 58 aa sequence (aa 312 - 369) which interacts with γ-secretase substrates. There are multiple splice variants of nicastrin. Over aa 34 - 669, human nicastrin shares 90% aa identity with mouse nicastrin.

Reactivity: Human, Mouse, Rat
Details: Rabbit IgG Polyclonal
Applications: IHC, WB, ELISA, ICC/IF
Western Blot: Nicastrin AntibodyBSA Free [NBP1-77269]
(4)

Recombinant Monoclonal Antibody

Reactivity: Human
Details: Rabbit IgG Monoclonal Clone #004
Applications: ICC/IF
Immunocytochemistry/ Immunofluorescence: Nicastrin Antibody (004) [NBP2-89826]
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