Neuropilin-1: Small Molecules and Peptides

Neuropilin-1 (NRP1) is a transmembrane glycoprotein that regulates axon guidance and angiogenesis. Distinct Neuropilin-1 domains mediate its binding to heparin, the heparin-binding forms of VEGF and PlGF (PlGF2), and Semaphorin 3. Neuropilin-1 can form homo- and hetero-oligomers with Neuropilin-2. Neuropilins show partially overlapping expression in neuronal and endothelial cells during development. They mediate axon repulsion on sensory and sympathetic neurons through binding to Class III ...